What Is 2-Fluoro-6-methoxyphenylboronic acid CAS 78495-63-3? Properties, Uses, and Buying Information

2-Fluoro-6-methoxyphenylboronic acid, CAS 78495-63-3, is an aryl boronic acid used primarily as a synthetic building block in organic and medicinal chemistry. Its structure combines a boronic acid group with fluoro and methoxy substituents on an aromatic ring, giving researchers a functional intermediate for carbon–carbon bond-forming reactions. At Maison Chemical, I supply this compound for research, process development, and qualified manufacturing projects, subject to product specification and availability.

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The compound is commonly associated with Suzuki–Miyaura coupling, in which an aryl boronic acid reacts with an aryl or vinyl halide under suitable catalytic and basic conditions. Its molecular formula is commonly represented as C₇H₈BFO₃, with a calculated molecular weight of approximately 169.95 g/mol. Because final suitability depends on purity, water content, packaging, and the buyer’s reaction system, I recommend confirming a current specification and certificate of analysis before placing a production order.

Identity and Core Chemical Functions

2-Fluoro-6-methoxyphenylboronic acid contains three chemically important features: an aryl boronic acid moiety, an aromatic fluorine substituent, and a methoxy group. The boronic acid group provides the principal coupling handle, while the fluoro and methoxy groups modify the electronic and steric environment of the aromatic ring. This combination can help chemists introduce a substituted aryl fragment into more complex molecules during route development.

The compound should be understood as a reactive intermediate rather than as a finished active ingredient. In a typical synthetic sequence, the boronic acid group is used to form a new carbon–carbon bond, after which the resulting product may undergo additional functional-group transformations. I do not treat the presence of a boronic acid group as a guarantee of reaction performance, because catalyst selection, base, solvent, temperature, substrate design, and work-up conditions all influence the result.

Basic Composition and Molecular Weight

For practical weighing, 1.00 mmol of the anhydrous formula corresponds to approximately 169.95 mg, and 10.0 mmol corresponds to approximately 1.6995 g. These values are calculated from the stated molecular weight and should not replace the molecular weight or water-content information shown on the batch documentation. If the supplied material is hydrated, partially solvated, or otherwise differs from the assumed form, the effective amount may need to be adjusted.

Properties and Handling Considerations

As an aromatic boronic acid, this material is generally handled as a solid chemical intermediate, but the exact appearance and physical behavior should be confirmed against the supplier’s current specification. Boronic acids can be sensitive to storage conditions, moisture exposure, and prolonged handling, and some may exist in equilibria involving boroxines or other forms. For this reason, I recommend keeping the container tightly closed and using the storage conditions stated on the label or certificate of analysis.

Laboratories should use appropriate chemical hygiene practices, including suitable gloves, eye protection, local ventilation, and documented operating procedures. The safety data sheet should be reviewed before opening the package, transferring the material, or beginning a reaction. I also recommend that buyers assess incompatibilities, waste requirements, and exposure controls through their own EHS process rather than relying only on a product name or catalog description.

What Buyers Should Verify

• Identity confirmation by an appropriate analytical method.
• Assay or purity specification required for the intended reaction.
• Water content or loss-on-drying information where moisture may affect the process.
• Residual solvents, inorganic residues, and other impurities when relevant to downstream use.
• Appearance, packaging condition, lot traceability, and retest or review information.

I use these points as a starting framework because a research-grade requirement may differ significantly from a process-development or manufacturing requirement. For example, a medicinal chemistry team may prioritize rapid availability and consistent small-pack supply, while a process team may require impurity profiling, larger quantities, and tighter lot-to-lot controls. The correct specification is therefore linked to the application, not simply to the CAS number.

Potential Applications

The main application of 2-fluoro-6-methoxyphenylboronic acid is as an intermediate for preparing substituted biaryl, heteroaryl–aryl, and related structures through palladium-catalyzed cross-coupling. Researchers may use it when a synthesis requires the controlled introduction of a fluoro-methoxy-substituted phenyl group. The resulting products can serve as intermediates in pharmaceutical discovery, agrochemical research, materials chemistry, or other advanced organic synthesis programs.

Medicinal and Pharmaceutical Research

In medicinal chemistry, fluorine and methoxy substitution are frequently explored as part of structure–activity relationship studies. This compound can provide a convenient route to analogues containing a specific substituted aromatic ring, although biological activity cannot be inferred from the intermediate itself. I recommend evaluating the compound based on its role in the planned synthetic route and confirming that the substitution pattern matches the target structure.

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Agrochemical and Materials Development

Outside pharmaceutical research, aryl boronic acids may be used to construct intermediates for crop-protection research, functional molecules, and specialized organic materials. The suitability of this particular compound depends on the required electronic properties, steric arrangement, and downstream functional groups. It should not be selected solely because it is a boronic acid; the complete target route and reaction compatibility should guide the decision.

Material Options and Specification Choices

Buyers may encounter this product in different commercial grades, package sizes, or documentation formats. The meaningful distinction is usually not a simple “standard” versus “premium” label, but whether the material specification supports the intended stage of work. I can discuss research quantities, project-based supply, and larger-volume requirements according to the available manufacturing and quality-control route.

For early screening, buyers may request a small quantity with basic identity and purity documentation. For scale-up, I recommend asking for a defined assay range, impurity limits, packaging configuration, lot consistency expectations, and a sample of the relevant documentation before approving the material. If a customer requires a particular analytical method, that method should be agreed in advance so that results can be interpreted consistently.

How to Select a Supplier

When sourcing CAS 78495-63-3, I suggest comparing more than the quoted price. Confirm that the supplier can identify the material unambiguously, provide batch-level documentation, communicate realistic lead times, and explain how the product is packaged and shipped. A clear answer to these points can reduce avoidable delays during reaction screening or process transfer.

1. Define the intended use: research screening, route development, scale-up, or recurring production.
2. Set the required specification: purity, water content, residual solvents, analytical method, and packaging.
3. Request documentation: certificate of analysis, safety data sheet, specification sheet, and lot information.
4. Confirm logistics: available quantity, lead time, shipping conditions, export documents, and delivery destination.
5. Review commercial fit: minimum order quantity, repeat-order capability, and communication during qualification.

One common purchasing mistake is selecting the lowest unit price without checking whether the offered material matches the required chemical form or documentation standard. Another is ordering a large quantity before confirming performance in the buyer’s own reaction system. I recommend starting with a technically appropriate sample or development quantity when possible, then moving to larger supply after identity, reaction performance, and handling requirements have been reviewed.

Maison Chemical Supplier Support

At Maison Chemical, I support B2B buyers who need 2-fluoro-6-methoxyphenylboronic acid for laboratory research, route development, or planned commercial programs. I can help organize product information, discuss quantity requirements, and align the quotation with the buyer’s requested specification. Where a project requires additional review, I encourage customers to provide the target quantity, destination country, application stage, and documentation expectations.

Supply conditions can vary by batch, order size, production schedule, and destination regulations, so I avoid presenting a fixed lead time or universal purity claim without reviewing the specific inquiry. I can instead provide current availability, applicable packaging options, commercial terms, and batch documentation for evaluation. This approach gives procurement and technical teams information they can use before approving a purchase.

Key Takeaways and Next Steps

2-Fluoro-6-methoxyphenylboronic acid CAS 78495-63-3 is an aryl boronic acid intermediate with a fluoro-methoxy-substituted aromatic structure and an approximate molecular weight of 169.95 g/mol. Its principal value is as a building block for cross-coupling and related organic synthesis, but actual performance depends on the reaction design and material specification. Handling should follow the supplier’s safety documentation and the buyer’s laboratory or manufacturing procedures.

If you are evaluating this compound, first confirm the required purity, quantity, analytical documentation, and intended application. Then request a current quotation and batch information from Maison Chemical so the technical and commercial fit can be reviewed together. For a B2B inquiry, please provide your required quantity, destination, target delivery schedule, and any specification or documentation requirements.

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