2-Bromophenylboronic Acid CAS 244205-40-1: Uses, Specifications, and Supplier Guide

I use this guide to help researchers, procurement teams, and process chemists evaluate 2-Bromophenylboronic acid, CAS 244205-40-1, before placing an inquiry. This compound is an ortho-bromo-substituted aryl boronic acid commonly considered as a building block for palladium-catalyzed cross-coupling, especially Suzuki–Miyaura chemistry. Its most important purchasing factors are verified identity, assay and impurity data, packaging, documentation, supply continuity, and suitability for the buyer’s specific reaction or development stage.

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2-Bromophenylboronic acid is generally represented by the molecular formula C₆H₆BBrO₂ and has a calculated molecular weight of approximately 200.83 g/mol. The molecule contains both an aryl bromide and a boronic acid functional group, giving chemists two useful handles for downstream synthesis. Because physical specifications and commercial availability can vary by supplier and batch, I recommend confirming the current specification sheet and certificate of analysis before purchasing.

What Is 2-Bromophenylboronic Acid?

2-Bromophenylboronic acid is an aromatic organoboron compound in which a boronic acid group and a bromine atom are attached to neighboring positions on a benzene ring. The CAS number 244205-40-1 is used to identify this specific chemical substance in purchasing, regulatory, and laboratory documentation. In practical synthesis planning, the compound is valued because the boronic acid group can participate in carbon–carbon bond formation while the aryl bromide may remain available for further transformation, depending on the reaction conditions.

Core Chemical Function

The primary synthetic role of this material is as an aryl boronic acid coupling partner. In a typical Suzuki–Miyaura reaction, the boronic acid group reacts with an appropriate aryl or vinyl halide in the presence of a suitable catalyst, base, and solvent system. The exact conversion, selectivity, and work-up requirements depend on the substrate combination and process conditions, so I do not treat the compound as a guaranteed solution for every coupling route.

Common Uses and Application Scenarios

I commonly position 2-Bromophenylboronic acid for research and development applications in medicinal chemistry, pharmaceutical intermediate synthesis, agrochemical research, and advanced organic synthesis. It can be used to introduce an ortho-substituted biaryl structure or to prepare more complex aromatic intermediates. It may also support route scouting when a project requires sequential functionalization of an aromatic ring.

Synthetic Building Block for Cross-Coupling

The boronic acid group is the most direct reason buyers select this compound. Researchers may combine it with aryl, heteroaryl, or vinyl electrophiles to explore substituted products, subject to catalyst compatibility and substrate reactivity. For stoichiometric planning, 1.00 mmol of pure material corresponds to approximately 200.83 mg based on the stated molecular weight; actual weighing should be adjusted according to the assay reported on the batch certificate.

Intermediate for Multi-Step Chemistry

The neighboring bromine atom provides additional synthetic flexibility, although its behavior must be evaluated under the selected reaction conditions. In some routes, the bromine is retained for a later transformation; in others, the boronic acid is used first and the remaining functionality is modified afterward. I recommend testing chemoselectivity on a small scale before committing to a larger process batch, particularly when multiple halides or sensitive functional groups are present.

Key Specifications Buyers Should Review

A buyer should review more than the product name and CAS number. I recommend requesting the current product specification, certificate of analysis, safety data sheet, analytical method information, and available batch details. These documents help distinguish identity confirmation from a supplier’s broader claims about performance or application suitability.

Theoretical molecular weight is a useful identity reference, but it is not a substitute for batch testing. For example, a 10.00 mmol calculation based on 200.83 g/mol gives a theoretical pure-material mass of 2.0083 g; the amount charged in practice should reflect the actual assay and any approved correction factor. I also advise buyers to check whether the supplier reports water or solvent content separately, because these values can affect both weighing and reaction reproducibility.

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How to Select the Right Grade and Supply Format

I start selection by defining the intended use: reaction screening, medicinal chemistry, kilo-lab development, or commercial process support. A small research project may prioritize rapid availability and flexible pack sizes, while a process-development team usually needs stronger batch documentation, repeatability, and a realistic replenishment plan. The correct grade is therefore determined by the application and internal quality requirements rather than by a single universal purity label.

Match the Material to the Project Stage

• Early screening: Confirm identity, usable assay, basic analytical data, and a practical research quantity.
• Route optimization: Request consistent batch information, impurity data, and a repeat-supply discussion.
• Scale-up preparation: Review manufacturing capability, quality documentation, packaging, lead-time expectations, and change-notification procedures.
• Regulated or quality-sensitive work: Establish the required documentation and acceptance criteria before issuing a purchase order.

I also compare the requested quantity with the supplier’s available production route and stock position. A quotation for a laboratory pack does not automatically demonstrate the ability to support larger quantities, and a larger offer does not automatically prove that the same quality profile will be maintained. Buyers should ask whether the quoted material is from an existing batch, planned production, or custom manufacturing schedule.

Procurement, MOQ, Pricing, and Lead-Time Considerations

Pricing for 2-Bromophenylboronic acid can change with quantity, assay, packaging, production route, documentation requirements, and delivery destination. Minimum order quantity should be evaluated together with shelf-life information, storage requirements, and the buyer’s expected consumption rate. I recommend asking for separate quotations for the intended research quantity and the next realistic scale so that the cost trend can be assessed without assuming a fixed market price.

Lead time should also be confirmed in writing because “available” may refer to domestic stock, supplier stock, or material requiring production and release. Before ordering, I suggest confirming the batch number or production status, estimated dispatch timing, shipping terms, export documentation, and whether a pre-shipment document review is possible. These checks reduce the risk of delays caused by missing SDS files, incorrect customs information, or an unsuitable package configuration.

Supplier Evaluation Checklist

Technical and Quality Questions

• Can the supplier confirm CAS 244205-40-1 and provide the current molecular formula and molecular weight?
• Is a batch-specific certificate of analysis available?
• Does the COA identify the analytical methods used for assay and relevant impurities?
• Can the supplier explain packaging, storage, transport, and handling recommendations?
• Is repeat supply available from a controlled and documented source?

Commercial and Service Questions

• What quantity is immediately available, and what quantity requires production?
• What are the MOQ, quotation validity, estimated lead time, and delivery terms?
• Can the supplier support export documentation and destination-specific requirements?
• Can the supplier discuss alternative pack sizes or a staged purchasing plan?
• How will specification changes or batch-to-batch differences be communicated?

At Maison Chemical, I approach an inquiry by first confirming the customer’s required quantity, application stage, destination, documentation needs, and target specification. I can help organize the relevant product information, including the available COA and SDS, subject to the specific batch and order requirements. I also recommend that customers send their intended specification and delivery timeline so that the quotation reflects a realistic supply option rather than a generic product listing.

Summary Insight

2-Bromophenylboronic acid CAS 244205-40-1 is a valuable aromatic boronic acid building block for cross-coupling and multi-step organic synthesis. Its calculated molecular weight is approximately 200.83 g/mol, and its combination of a boronic acid group with an aryl bromide creates useful but condition-dependent synthetic flexibility. The most reliable purchasing decision comes from matching the compound’s documented batch quality, quantity, packaging, and supply continuity to the actual project requirement.

Conclusion and Next Steps

If you are evaluating 2-Bromophenylboronic acid, I recommend confirming identity first, then reviewing assay, impurity information, documentation, storage instructions, MOQ, price, and lead time. For a new reaction route, begin with a controlled screening quantity and verify performance under your own conditions rather than relying only on a general application description. For repeat or scale-up purchasing, request a supply plan and batch documentation before approval.

Maison Chemical can support a structured B2B inquiry for 2-Bromophenylboronic acid CAS 244205-40-1. Send your required quantity, target specification, packaging preference, destination, and requested documents, and I can help prepare the next procurement discussion based on the material and service requirements you provide.

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