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Jun. 05, 2025
Andallu B, Suryakantham V, Lakshmi Srikanthi B, Reddy GK. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta ;314:47-53. View abstract.
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Andallu B, Varadacharyulu NC. Antioxidant role of mulberry (Morus indica L. cv. Anantha) leaves in streptozotocin-diabetic rats. Clin Chim Acta ;338:3-10. View abstract.
Andallu B, Varadacharyulu NC. Gluconeogenic substrates and hepatic gluconeogenic enzymes in streptozotocin-diabetic rats: effect of mulberry (Morus indica L.) leaves. J Med Food ;10:41-8. View abstract.
Asano N, Oseki K, Tomioka E, et al. N-containing sugars from Morus alba and their glycosidase inhibitory activities. Carbohydr Res ;259:243-55. View abstract.
Asano N, Yamashita T, Yasuda K, et al. Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.). J Agric Food Chem ;49:-13. View abstract.
Chen J, Li X. Hypolipidemic effect of flavonoids from mulberry leaves in triton WR- induced hyperlipidemic mice. Asia Pac J Clin Nutr ;16(Suppl 1):290-4. View abstract.
Da Villa G, Ianiro G, Mangiola F, et al. White mulberry supplementation as adjuvant treatment of obesity. J Biol Regul Homeost Agents ;28(1):141-5. View abstract.
Doi K, Kojima T, Makino M, et al. Studies on the constituents of the leaves of Morus alba L. Chem Pharm Bull ;49:151-3. View abstract.
Du J, He ZD, Jiang RW, et al. Antiviral flavonoids from the root bark of Morus alba L. Phytochemistry ;62:-8. View abstract.
El-Beshbishy HA, Singab AN, Sinkkonen J, Pihlaja K. Hypolipidemic and antioxidant effects of Morus alba L. (Egyptian mulberry) root bark fractions supplementation in cholesterol-fed rats. Life Sci ;78:-33. View abstract.
Enkhmaa B, Shiwaku K, Katsube T, et al. Mulberry (Morus alba L) leaves and their major flavonol quercetin 3-(6-malonylglucoside) attenuate atherosclerotic lesion development in LDL receptor-deficient mice. J Nutr ;135:729-34. View abstract.
Gurukar MSA, Chilkunda ND. Morus alba leaf bioactives modulate peroxisome proliferator activated receptor ? in the kidney of diabetic rat and impart beneficial effect. J Agric Food Chem ;66(30):-34. doi: 10./acs.jafc.8b. View abstract.
Hansawasdi C, Kawabata J. Alpha-glucosidase inhibitory effect of mulberry (Morus alba) leaves on Caco-2. Fitoterapia ;77:568-73. View abstract.
Huh HW, Na YG, Bang KH, et al. Extended intake of mulberry leaf extract delayed metformin elimination via inhibiting the organic cation transporter 2. Pharmaceutics. ;12(1):49. View abstract.
Hwang KH, Kim YK. Promoting effect and recovery activity from physical stress of the fruit of Morus alba. Biofactors ;21:267-71. View abstract.
Jeong HI, Jang S, Kim KH. Morus alba L. for Blood Sugar Management: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med ;:. View abstract.
Jung S, Lee MS, Choi AJ, Kim CT, Kim Y. Anti-Inflammatory effects of high hydrostatic pressure extract of mulberry (Morus alba) fruit on LPS-stimulated RAW264.7 cells. Molecules ;24(7):0. pii: E. doi: 10./molecules. View abstract.
Kimura T, Nakagawa K, Kubota H, et al. Food-grade mulberry powder enriched with 1-deoxynojirimycin suppresses the elevation of postprandial blood glucose in humans. J Agric Food Chem ;55:-74. View abstract.
Lee J, Chae K, Ha J, et al. Regulation of obesity and lipid disorders by herbal extracts from Morus alba, Melissa officinalis, and Artemisia capillaris in high-fat diet-induced obese mice. J Ethnopharmacol ;115:263-70. View abstract.
Lee SH, Choi SY, Kim H, et al. Mulberroside F isolated from the leaves of Morus alba inhibits melanin biosynthesis. Biol Pharm Bull ;25:-8. View abstract.
Li R, Xue Z, Jia Y, et al. Polysaccharides from mulberry (Morus alba L.) leaf prevents obesity by inhibiting pancreatic lipase in high-fat diet induced mice. Int J Biol Macromol ;192:452-460. View abstract.
Moore LM. Plant Guide: White Mulberry. United States Department of Agriculture, Natural Resources Conservation Service. Available at: https://plants.usda.gov/plantguide/pdf/pg_moal.pdf. (Accessed 3 September ).
Mudra M, Ercan-Fang N, Zhong L, et al. Influence of mulberry leaf extract on the blood glucose and breath hydrogen response to ingestion of 75 g sucrose by type 2 diabetic and control subjects. Diabetes Care ;30:-4. View abstract.
Oku T, Yamada M, Nakamura M, et al. Inhibitory effects of extractives from leaves of Morus alba on human and rat small intestinal disaccharidase activity. Br J Nutr ;95:933-8. View abstract.
Park KM, You JS, Lee HY, et al. Kuwanon G: an antibacterial agent from the root bark of Morus alba against oral pathogens. J Ethnopharmacol ;84:181-5. View abstract.
Skupien K, Kostrzewa-Nowak D, Oszmianski J, Tarasiuk J. In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells. Phytother Res ;22:689-94. View abstract.
Taghizadeh M, Mohammad Zadeh A, Asemi Z, et al. Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial. Clin Nutr ESPEN ;49:68-73. View abstract.
Thaipitakwong T, Supasyndh O, Rasmi Y, Aramwit P. A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes. Complement Ther Med. ;49:. View abstract.
Thondre PS, Lightowler H, Ahlstrom L, Gallagher A. Mulberry leaf extract improves glycaemic response and insulaemic response to sucrose in healthy subjects: results of a randomized, double blind, placebo-controlled study. Nutr Metab (Lond) ;18(1):41. View abstract.
Trimarco V, Izzo R, Stabile E, et al. Effects of a new combination of nutraceuticals with Morus alba on lipid profile, insulin sensitivity and endothelial function in dyslipidemic subjects. A cross-over, randomized, double-blind trial. High Blood Press Cardiovasc Prev ;22(2):149-54. doi: 10./s-015--2. View abstract.
Wan M, Li Q, Lei Q, Zhou D, Wang S. Polyphenols and Polysaccharides from Morus alba L. Fruit Attenuate High-Fat Diet-Induced Metabolic Syndrome Modifying the Gut Microbiota and Metabolite Profile. Foods ;11(12):. View abstract.
Wattanathorn J, Somboonporn W, Sungkamanee S, Thukummee W, Muchimapura S. A double-blind placebo-controlled randomized trial evaluating the effect of polyphenol-rich herbal congee on bone turnover markers of the perimenopausal and menopausal women. Oxid Med Cell Longev ; 21::. doi: 10.//. View abstract.
Yu Z, Fong WP, Cheng CH. The dual actions of morin (3,5,7,2',4'-pentahydroxyflavone) as a hypouricemic agent: uricosuric effect and xanthine oxidase inhibitory activity. J Pharmacol Exp Ther ;316:169-75. View abstract.
Mulberries contain iron, vitamin C, and compounds. Eating them may help reduce cholesterol, blood sugar, and cancer risk. They have been used in Chinese herbal medicine to treat different ailments, but the evidence is limited.
Mulberries are the fruits of mulberry trees (Morus sp.) and related to figs and breadfruit.
The trees are traditionally grown for their leaves — mainly in Asia and North America — as they’re the only food that silkworms eat (1).
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They carry colorful berries — most commonly black, white, or red — that are often made into wine, fruit juice, tea, jam, or canned foods, but can also be dried and eaten as a snack.
Due to their sweet flavor, impressive nutritional value, and various health benefits, mulberries are gaining popularity worldwide (2).
This article reviews mulberries, including their nutrition and benefits.
Fresh mulberries consist of 88% water and only have 60 calories per cup (140 grams).
By fresh weight, they provide 9.8% carbs, 1.7% fiber, 1.4% protein, and 0.4% fat.
Mulberries are often consumed dried, similar to raisins. In this form, they contain 70% carbs, 14% fiber, 12% protein, and 3% fat — making them fairly high in protein compared to most berries.
Here are the main nutrients in a 3.5-ounce (100-gram) serving of fresh mulberries (3):
Fresh mulberries consist of 9.8% carbs, or 14 grams per cup (140 grams).
These carbs are mostly simple sugars, such as glucose and fructose, but also contain some starch and fiber.
Mulberries have a decent amount of fiber, corresponding to 1.7% of their fresh weight.
The fibers are both soluble (25%) in the form of pectin and insoluble (75%) in the form of lignin (1, 4).
Fibers help you maintain a healthy digestive system, decrease cholesterol levels, and reduce your risk of many diseases (5, 6, 7, 8).
SUMMARYFresh mulberries have about 10% carbs in the form of simple sugars, starch, and soluble and insoluble fibers. They’re fairly high in water and low in calories.
Mulberries are rich in many vitamins and minerals, particularly vitamin C and iron:
SUMMARYMulberries contain high amounts of both iron and vitamin C, as well as decent amounts of potassium and vitamins E and K.
Mulberries are rich in plant compounds, such as anthocyanins, that contribute to their color and beneficial health effects (15, 16, 17, 18, 19).
The most abundant ones include:
The amounts of plant compounds in mulberries depends on the variety. This results in different colors and antioxidant properties (27).
Deep-colored and mature mulberries are richer in plant compounds and have a higher antioxidant capacity than colorless and immature berries (28, 29, 30, 31).
SUMMARYMulberries contain several plant compounds, such as anthocyanins, chlorogenic acid, rutin, and myricetin. Deep-colored and mature berries are richer in these compounds than colorless berries.
Mulberries or mulberry extracts may be beneficial against several chronic conditions, such as heart disease, diabetes, and cancer (32).
Cholesterol is an important fatty molecule present in every cell of your body. However, elevated blood cholesterol levels are linked to increased heart disease risk.
Animal studies show that mulberries and mulberry extracts can reduce excess fat and lower cholesterol levels. They may also improve the ratio between LDL (bad) and HDL (good) cholesterol (20, 33).
Additionally, some test-tube experiments suggest that they reduce the formation of fat in the liver — potentially helping prevent fatty liver disease (34, 35, 36, 37).
People with type 2 diabetes are at risk of a rapid rise in blood sugar and need to be careful when they eat carbs.
Mulberries contain the compound 1-deoxynojirimycin (DNJ), which inhibits an enzyme in your gut that breaks down carbs.
Therefore, mulberries may be beneficial against diabetes by slowing down the increase in blood sugar after meals. Studies in people are needed before any firm conclusions can be reached (38, 39, 40).
Increased stress in your body has been shown to induce oxidative damage in cells and tissues, which is associated with increased cancer risk (41, 42).
For hundreds of years, mulberries have been part of traditional Chinese medicine as a remedy against cancer.
Some researchers now believe that these reputed cancer-preventive effects may have a scientific basis (43).
Keep in mind that the same applies to fruits and vegetables in general. No evidence suggests that mulberries reduce cancer risk more than other fruits or berries.
SUMMARYMulberries may lower cholesterol levels, help prevent fatty liver disease, and improve blood sugar control. They also decrease oxidative stress, which may reduce cancer risk.
Mulberries are colorful berries that are eaten both fresh and dried.
They’re a good source of iron, vitamin C, and several plant compounds and have been linked to lower cholesterol, blood sugar, and cancer risk.
These berries have also been used in Chinese herbal medicine for thousands of years to treat various illnesses, though evidence to support their effectiveness is weak.
Mulberries have a sweet and delicious taste, are packed with nutrients, and have a range of potential health benefits — which are all important for building a healthy diet.
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