Alamdar Hussain, Ph.D.
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Assistant Dean of Student Affairs and Admission / Associate Professor of Pharmaceutical Sciences
Education
Ph.D., Pharmaceutics, Texas Tech University Health Sciences Center, Amarillo, TX
B.S. in Pharmacy, Kakatiya University, Warangal, India
Bio
Dr. Hussain received his Ph.D. in Pharmaceutics from the Graduate School of Biomedical Sciences at Texas Tech University Health Sciences Center in Amarillo, TX, and his B.S. in Pharmacy from Kakatiya University in India. Prior to joining AUHS, Dr. Hussain worked as Assistant Professor of Pharmaceutical Sciences at the Universities of Louisiana and Oklahoma. He has taught both professional pharmacy and graduate students various courses including but not limited to Pharmaceutics, Compounding Pharmacy, Pharmacokinetics, Physical Pharmacy, Advanced Drug Delivery and Targeting, Pharmaceutical Technology, Medical Microbiology, and Biotechnology. He has also mentored several M.S. and Ph.D. students throughout his career.
Dr. Hussain’s research interest primarily focuses in the field of inhalation protein and peptide drug delivery. He is currently investigating ways to improve absorption of drugs by non-invasive routes in laboratory animals and understand mechanisms of macromolecular drug transport in vitro. Dr. Hussain is also passionate about student learning and implements novel methods of teaching and learning in classroom and laboratory. He is actively pursuing the arena of Scholarship of Teaching and Learning after joining AUHS in .
With regard to his leadership experience, Dr. Hussain is a former Chair of the Department of General Education at AUHS. Currently, he serves as the Assistant Dean for Student Affairs and Admission for the School of Pharmacy.
Selected Publications (Since )
E. Nguyen, S. Kim, M. Islam, Y. Chang, J. Aoyagi, A. Hussain (). An entrepreneurial activity implementation and assessment among pharmacy students amid the COVID-19 pandemic lockdown. Pharmacy Education, 22(1):16-22.
A. Hussain, H. Chau, H. Bang, L. Meyer, M. Islam (). Performance of pharmacy students in a communications course delivered online during the COVID-19 pandemic. American Journal of Pharmaceutical Education, 85(10): Article .
A. Hussain (). Implementation of online assignment submission with instant feedback in a pharmacy course. Pharmacy Education, 21(1):45-50.
D. Raghuvanshi, G. Nkepang, A. Hussain, H. Yari, V. Awasthi (). Stability studies on an anticancer drug 4-(3.5-bis (2-chlorobenzylidene)-4-oxo-piperidine)-4-oxo-2-butenoic acid (Clefma) using a stability indicating HPLC method. Journal of Pharmaceutical Analysis, 7(1):1-9.
G. Rao, A. Hedrick, V. Yadav, J. Xie, A. Hussain, V. Awasthi (). The brain metabolic activity after resuscitation with liposome-encapsulated hemoglobin in a rat model of hypovolemic shock. Journal of Cerebral Blood Flow Metabolism, 35(9):-36.
K. Amancha, A. Hussain (). Effect of protease inhibitors on pulmonary bioavailability of therapeutic proteins and peptides in the rat. European Journal of Pharmaceutical Sciences, 20(68):1-10.
V. Yadav, A. Hussain, J Xie, S. Kosanke, V. Awasthi (). The salutary effects of diphenyldifluoroketone EF24 in liver of a rat hemorrhagic shock model. Scandinavian Journal of Trauma Resuscitation and Emergency Medicine, 23:8.
V. Yadav, A. Hussain, K. Sahoo, V. Awasthi (). Remediation of hemorrhagic shock-induced intestinal barrier dysfunction by treatment with diphenyldihaloketones, EF24 and Clefma. Journal of Pharmacology and Experimental Therapeutics, 351(2):413-422.
K. Amancha, S. Balkundi, Y. Lvov, A. Hussain (). Pulmonary sustained release of insulin from microparticles composed of polyelectrolyte layer-by-layer assembly. International Journal of Pharmaceutics, 466(1-2)96-108.
Dr. Robert H. Zeiler, Professor of Pathophysiology, School of Pharmacy and Professor of Physiology, School of Medicine.
BIO
Dr. Robert H. Zeiler, Professor of Pathophysiology, School of Pharmacy and Professor of Physiology, School of Medicine, has scientific degrees from Long Island University (B.S., Biology, and M.S. Physiology, ) and earned his doctorate in Biology from New York University, Washington Square, . Prior to entering the pharmaceutical industry, he performed original research in cardiac electrophysiology and biophysics, particularly in arrhythmia and ischemia, publishing in over 50 abstracts, presentations and peer-reviewed journals.
EDUCATION
Doctor of Philosophy, Biology
New York University
Graduate School of Arts and Science
Washington Square
New York, New York, USA
Master of Science, Physiology
Long Island University
Flatbush Avenue Extension
Brooklyn, New York, USA
Bachelor of Science, Biology
Long Island University
Flatbush Avenue Extension
Brooklyn, New York, USA
MEMBERSHIPS
to Present American Heart Association
to Present Society of Quality Assurance
PUBLICATIONS AND PRESENTATIONS
1. Gelles JM and Zeiler RH: “ELECTRO-MECHANICAL COUPLING IN CARDIAC MUSCLE; EFFECTS OF CALCIUM IONOPHORES.” Circulation, 55 and 66: III-46, .
2. Gelles JM and Zeiler RH: “IS NA-CA EXCHANGE IN CARDIAC PURKINJE FIBERS ELECTROGENIC?.” Fed. Proceedings, 37:3, , .
3. Zeiler RH, Gelles JM, and Krasnow N: “THE EFFECTS OF NATURAL AND SYNTHETIC IONOPHORES ON THE ACTION POTENTIAL AND ISOMETRIC CONTRACTION OF CARDIAC PURKINJE FIBERS.” Fed. Proceedings, 37.3, , .
4. Gelles JM, Zeiler RH, and Krasnow N: “ELECTRO-MECHANICAL COUPLING IN CARDIAC PURKINJE FIBERS: EFFECTS OF IONOPHORE X-537A.” Bull. N.Y. Aced. Med. 54-3: 316-317, .
5. Gelles JM and Zeiler RH: “ELECTROGENIC HYPERPOLARIZATION IN CANINE CARDIAC PURKINJE FIBERS EXPOSED TO CALCIUM IONOPHORES.” Experientia 34:619, .
6. El-Sherif N, Gomes JAC, Kelen GJ, Khan RG, Kang PS, and Zeiler RH: “ELECTRO-PHYSIOLOGIC, BIOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF REENTRANT VENTRICULAR ARRHYTHMIAS IN THE LATE MYOCARDIAL INFARCTION PERIOD. “IN: “SUDDEN DEATH.”
7. El-Sherif N, Gomes JAC, Kelen GJ, Khan RG Kang PS, and Zeiler RH: “ELECTRO-PHYSIOLOGY OF REENTRANT VENTRICULAR ARRHYTHMIAS IN THE LATE MYOCARDIAL INFARCTION PERIOD.” In: “New Trends in Medical and Surgical Management of Tachyarrhythmias.” Editors, L. Seipl, H.D. Schulti. .
8. El-Sherif N, Zeiler RH, Gough W: “EFFECTS OF CATECHOLAMINES, VERAPA¬MIL AND TETRODOTOXIN ON TRIGGERED AUTOMATICITY IN CANINE ISCHEMIC PURKINJE FIBERS.” Circulation 62: Suppl. III; , .
9. Zeiler RH, Gough WB, Sung R, El-Sherif N: “ELECTROPHYSIOLOGIC EFFECT OF PROPAFENONE IN CANINE ISCHEMIC CARDIAC CELLS.” Am. J. Cardiol, 47:483, .
10. El-Sherif N, Gough, WB, Zeiler RH, Mehra R: “EPICARDIAL MAPPING OF TRIGGERED
AUTOMATICITY IN CANINE ISCHEMIC PURKINJE FIBERS.” Am. J. Cardiol., 47:489, .
11. Gough WB, Zeiler RH, El-Sherif N: “THE ANTIARRHYTHMIC ACTION OF NIFEDIPINE ON TRIGGERED ACTIVITY IN ONE DAY OLD ISCHEMIC ENDOCARDIUM.” Circulation 64: Suppl. IV; 274, .
12. El-Sherif N, Gough WB, Zeiler RH, Mehra R: “DIFFERENT MECHANISMS FOR SPONTANEOUS AND INDUCED VENTRICULAR RHYTHMS IN 24 HOUR-OLD MYOCARDIAL INFARCTION IN THE DOG.” Circulation 64: Suppl. IV; 218, .
13. Mehra R, Zeiler RH, Gough WB, El-Sherif N: “MECHANISM OF REPETITIVE VENTRICULAR RESPONSES RVR’S BLOCK.” Circulation 64: Suppl. IV; 172, .
14. Gough WB, Zeiler RH, Barreca P, El-Sherif N: “THE HYPOTENSIVE EFFECTS OF COMMERCIAL INTRAVENOUS AMIODARONE IN DOGS: DEPENDENCE ON THE DILUENT POLYSORBATE 80.” J. of Cardiovascular Pharm., 4:375-380, .
15. Mehra R, Kelen GJ, Zeiler RH, Zephiran D, Fried P, Gomes JA, El-Sherif N: “NON-INVASIVE HIS BUNDLE ELECTROGRAM: VALUE OF THREE VECTOR LEAD RECORDINGS.” Am. J. Cardiol., 49:344-348, .
16. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “VENTRICULAR RHYTHMS IN CANINE ONE-DAY-OLD MYOCARDIAL INFARCTION. EVIDENCE FOR FOCAL AND REENTRANT MECHANISMS.” Circulation Research, 51:152-166, .
17. Mehra R, Zeiler RH, Gough WB, El-Sherif N: “REENTRANT VENTRICULAR ARRHYTHMIAS IN THE LATE MYOCARDIAL INFARCTION PERIOD. 9. ELECTROPHYSIOLOGICAL ANATOMICAL CORRELATION OF REENTRANT CIRCUITS.” Circulation. 67(1):11-24, January, .
18. Gough WB, Zeiler RH, El-Sherif N: “EFFECTS OF CALCIUM AND CALCIUM ANTAGONISTS ON TRIGGERED ACTIVITY IN ONE-DAY-OLD CANINE ISCHEMIC ENDOCARDIUM.” Am J. Cardiol., 49:914, .
19. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “MECHANISM OF REENTRANT RHYTHMS INDUCED BY BURSTS OF RAPID VENTRICULAR STIMULATION IN THE ISCHEMIC CANINE HEART.” Am J. Cardiol., 49:934, .
20. Zeiler RH, Strand FL, El-Sherif N: “CANINE LEFT ATRIAL TISSUE SPECIFICALLY BINDS ADRENOCORTICOTROPIC HORMONE.” Am. J. Cardiol., 49:, .
21. Zeiler RH, Strand FL, El-Sherif N: “ELECTROPHYSIOLOGICAL AND CONTRAC¬TILE RESPONSES OF CANINE ATRIAL TISSUE TO ADRENOCORTI¬COTRO¬PIN.” Peptides, 3:815, .
22. Zeiler RH, Gough WB, El-Sherif N: “ROLE OF CA2+ AND NA2+ ON AFTER DEPOLARIZATIONS IN CANINE ISCHEMIC PURKINJE FIBERS.” Circulation, 66:II-78, .
23. Gough WB, Zeiler RH, El-Sherif N: “BASIS FOR REDUCED TRANSMEMBRANE POTENTIALS ASSORTED WITH TRIGGERED ACTIVITY IN ISCH¬EMIC SUBENDOCARDIAL PURKINJE FIBERS.” Circulation, 66:II-156, .
24. Hariman RJ, Zeiler RH, Gough WB, El-Sherif N: “THE EFFECT OF OUABAIN ON TRIGGERED ACTIVITY IN ONE DAY ONE CANINE INFARCTION.: Circulation, 66:II, .
25. El-Sherif N, Gough WB, Zeiler RH, Mehra R: “VENTRICULAR RHYTHMS IN ONE-DAY-OLD CANINE INFARCTION ARE DUE TO TRIGGERED ACTIVITY.” Circulation, 66:II-357, .
26. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “TERMINATION OF REENTRANT CIRCUITS IN CANINE INFARCTION BY CRYOTHERMAL TECH¬NIQUES.” Circulation, 66:II-358, .
27. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “VENTRICULAR ACTIVATION PATTERNS OF SPONTANEOUS AND INDUCED VENTRICULAR RHYTHMS IN CANINE ONE-DAY-OLD MYOCARDIAL INFARCTION.” Circulation Research, 51:152-166, .
28. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “VENTRICULAR ACTIVATION PATTERNS OF PLEOMORPHIC VENTRICULAR TACHYCARDIAS THAT TERMINATE SPONTANEOUSLY OR DEGENERATE INTO VENTRICULAR FIBRILLATION.” J. American College of Cardiology, 2:621, .
29. Gough WB, Zeiler RH, El-Sherif N: “EFFECTS OF DILTIAZEM ON TRIGGERED ACTIVITY IN ONE-DAY-OLD ISCHEMIC ENDOCARDIUM OF THE DOG.” J. American College of Cardiology, 2:692, .
30. Mehra E, Zeiler RH, Gough WB, El-Sherif N: “REENTRANT VENTRICULAR ARRHYTHMIAS CORRELATION OF REENTRANT CIRCUITS. THE ANATOM¬ICAL BASIS FOR REENTRY.” Circulation 67(1):11-24, .
31. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “EFFECTS OF REVERSIBLE COOLING ON REENTRANT TACHYCARDIA IN CANINE INFARCTION.” Pace, 6:5, .
32. El-Sherif N, Gough WB, Zeiler RH, Mehra R: “TRIGGERED RHYTHMS IN ONE-DAY-OLD MYOCARDIAL INFARCTION IN THE DOG.” Circulation Research, 52:566-579, .
33. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “REENTRANT VENTRICULAR ARRHYTHMIAS IN THE LATE MYOCARDIAL INFARCTION PERIOD AND INTERRUPTION OF REENTRANT CIRCUITS BY CRYOTHERMAL TECHNIQUES.” Circulation, 63:644-656, .
34. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “EFFECTS OF REVERSIBLE COOLING ON REENTRANT TACHYCARDIAS IN CANINE INFARCTION.” Physiologist 26:A91, .
35. Gough WB, Zeiler RH, El-Sherif N: “EFFECTS OF CAFFEINE ON TRIGGERED ACTIVITY IN ONE-DAY-OLD ISCHEMIC ENDOCARDIUM OF THE DOG.” Circulation 68:III-20, .
36. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “BURST PACING VERSUS PREMATURE STIMULATION IN THE INDUCTION OF REENTRY.” J. Amer. Coll. Cardiol. 3:587, .
37. Mehra R, Gough WB, Zeiler RH, El-Sherif N: “MECHANISM OF LIDOCAINE ACTION ON REENTRANT VENTRICULAR RHYTHMS IN THE CANINE ISCHEMIC HEART.” J. Amer. Coll. Cardiol. 3:542, .
38. Gough WB, Zeiler RH, El-Sherif N: “EFFECTS OF NIFEDIPINE ON TRIGGERED ACTIVITY IN ONE-DAY-OLD MYOCARDIAL INFARCTION IN DOGS.” Amer. J. Cardiol. 53:303-306, .
39. Mehra R, Gough WB, Zeiler RH, El-Sherif N: “DUAL VENTRICULAR STIMULA¬TION FOR PREVENTION OF REENTRANT VENTRICULAR ARRHYTH¬MIAS.” J. Amer. Coll. Cardiol. 3:472, .
40. Gough WB, Zeiler RH, El-Sherif N: “DEPENDENCE OF TRIGGERED ACTIVITY ON DIASTOLIC POTENTIALS IN ONE-DAY-OLD ISCHEMIC PURKINJE FIBERS.” J. Amer. Coll. Cardiol. 3:477, .
41. El-Sherif N, Gough WB, Zeiler RH: “THE EFFECT OF DIFFERENTIAL SHORTENING OF REFRACTORINESS IN SUCCESSIVE SHORT CARDIAC CYCLES ON THE INITIATION AND TERMINATION OF REENTRY IN THE ISCHEMIC CANINE HEART.” J. Amer. Coll. Cardiol. 3:477, .
42. Zeiler RH, Gough WB, El-Sherif N: “ELECTROPHYSIOLOGIC EFFECT OF PROPAFENONE ON CANINE ISCHEMIC CARDIAC CELLS.” Amer. J. Cardiol. 54:424-429, .
43. El-Sherif N, Mehra R, Gough WB, Zeiler RH: “REENTRANT VENTRICULAR ARRHYTHMIAS IN THE LATE MYOCARDIAL INFARCTION PERIOD: II. BURST PACING VERSUS MULTIPLE PREMATURE STIMULATION IN THE INDUCTION OF REENTRY.” J. Amer. Coll. Cardiol. 4:295-304, .
44. Zeiler RH, Tobiasz C, Henkin R, Gough WB, El-Sherif N: “THE EFFECTS OF ISCHEMIA ON INTRACELLULAR POTASSIUM ACTIVITY AND MEMBRANE POTENTIAL IN CANINE ENDOCARDIAL TISSUE.” Circulation, 70(4): 898, .
45. Gough WB, Zeiler RH, El-Sherif N: “EFFECTS OF DILTIAZEM ON TRIGGERED ACTIVITY IN CANINE ONE-DAY-OLD INFARCTION. Cardiovasc Res 18:339-343, .
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46. El-Sherif N, Gough WB, Hariman R, Zeiler RH: “MECHANISMS OF TERMINATION OF ACCELERATION OF REENTRANT TACHYCARDIA BY BURST PACING.” Circulation, 70:II-91, .
47. Hariman RH, Zeiler RH, Gough WB, El-Sherif N: “ENHANCEMENT OF TRIGGERED ACTIVITY IN ISCHEMIC PURKINJE FIBERS BY OUABAIN. A MECHANISM OF INCREASED SUSCEPTIBILITY TO DIGITALIS TOXICITY IN MYOCARDIAL INFARCTION.” J. Amer. Coll. Card. 5(3):672-679, .
48. El-Sherif N, Gough WB, Hariman R, Zeiler RH: “ROLE OF NON UNIFORM REFRACTORY DISTRIBUTION VERSUS ANISOTROPIC ANATOMIC PROPERTIES IN THE INITIATION OF REENTRANT EXCITATION IN THE CANINE POST-INFARCTION HEART.” J. Amer. Coll. Card. 5:390, .
49. El-Sherif N, Gough WB, Zeiler RH, and Hariman R: “REENTRANT VENTRICULAR ARRHYTHMIAS IN THE LATE MYOCARDIAL INFARCTION PERIOD. 12. SPONTANEOUS VERSUS INDUCED REENTRY AND INTRA¬MURAL VERSUS EPICARDIAL CIRCUITS. J. Am. Coll. Cardiol. 6(1):124-132, .
50. Gough WB, Mehra R, Restive M, Zeiler RH and El-Sherif N: “REENTRANT VENTRICULAR ARRHYTHMIAS IN THE LATE MYOCARDIAL INFARCTION PERIOD IN DOG. 13. CORRELATION OF ACTIVATION AND REFRACTORY MAPS.” Circ. Res. 57(3):432-442, .
51. El-Sherif N, Gough WB, Zeiler RH, Craelius W, and Restivo M: “ROLE OF NON UNIFORM REFRACTORY DISTRIBUTION VERSUS ANISOTROPIC PROPERTIES IN THE INITIATION OF REENTRANT EXCITATION IN THE CANINE POST INFARCTION HEART.” J. Amer. Coll. Cardiol. 5(2):390, .
52. Fontaine JM, Zeiler RH, Henkin R, El-Sherif N: “SIMULTANEOUS MONOPHASIC ACTION POTENTIAL RECORDING AND REGIONAL ENDOCARDIAL REFRACTORY PERIOD DETERMINATION USING A NEW DUAL PUR¬POSE CONTACT ELECTRODE CATHETER., PACE 9(2):278, .
53. Craelius W, Chen V, El-Sherif N, and Zeiler RH: “IN VIVO RECORDING OF EARLY AFTER DEPOLARIZATION PRECEDING TORSADES DE POINTES.” J. Amer. Coll. Cardiol. 7:124A, .
54. Kelen GJ, Henkin R, Restivo M, Zeiler RH, Caref EB, and El-Sherif N: “SIGNAL AVERAGING OF HIGH GAIN HOLTER ECG RECORDINGS VALIDATION OF A NEW TECHNIQUE FOR DETECTION OF AFTER POTENTIALS.” J. Amer. Coll. Cardiol. 7:104A, .
55. Zeiler RH, Sequeira JM, Henkin R, Sedlis SP, El-Sherif N: “LYSOPHOSPHATIDYL CHOLINE: PROBABLE AGENT FOR MAINTAINED TRIGGERED ACTIVITY IN ISCHEMIC CARDIAC PURKINJE FIBERS.” J. Amer. Coll. Cardiol. 9:252, .
56. El-Sherif N, Zeiler RH, Craelius W, Henkin R, Gough WB: “BRADYCARDIA-DEPENDENT QTU PROLONGATION AND TORSADES-DE-POINTES DUE TO EARLY AFTER-DEPOLARIZATIONS.” Circulation 76:429, .
57. El-Sherif N, Zeiler RH, Craelius W, Gough WB, Henkin R: “2:1 BLOCK OF AN EARLY AFTER-DEPOLARIZATION AS A MECHANISM FOR TB ALTERNANS.” J. Amer. Coll. Cardiol. 11:254A, .
58. El-Sherif N, Zeiler RH, Craelius W, Gough WB, Henkin R. QTU PROLONGATION AND POLYMORPHIC VENTRICULAR TACHYARRHYTHMIAS DUE TO BRADYCARDIA DEPENDENT EARLY AFTERDEPOLARIZATIONS. Circ Res. ; 63:286-305.
Jonathan Sheng, PhD
Assistant Professor of Pharmaceutical Sciences (Adjunct/Part-time Faculty)
Education
Post-Ph. D. Pharmaceutical Sciences/Medicinal Chemistry
Division of Medicinal and Natural Products Chemistry
College of Pharmacy, University of Iowa, Iowa City, Iowa
Ph. D. Toxicology/Drug Metabolism
Department of Environmental Health Sciences and Toxicology
School of Public Health, State University of New York, Albany, New York
B. M. Medicine
Kunming Medical University, Kunming, China
Bio
Dr. Jonathan Sheng received his Ph.D. training in Environmental Sciences and Toxicology at State University of New York at Albany and his post-doctoral training in Medicinal Chemistry/Pharmaceutical Sciences at the University of Iowa. He currently is a regular member of American Chemical Society (ACS), American Association of Pharmaceutical Scientists (AAPS), American Society for Pharmacology and Experimental Therapeutics (ASPET), and International Society for the Study of Xenobiotics (ISSX).
Dr. Sheng’s research interests and expertise are in the areas of drug and xenobiotic metabolism, drug analysis (both small molecules and biological molecules), enzymology (P450s and cytosolic sulfotransferases), protein chemistry (protein structure/function, molecular mobility, subcellular localization, and stereochemistry), transgenic animal model development, and drug/environmental chemical-protein interaction studies.
Publications
S heng, J.J, Wang, Y, Turesky, R.J., Kluetzman K, Zhang Q.Y., Ding X. () Novel Transgenic Mouse Model for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure. Chemical Research in Toxicology 29:797-809
S heng, J.J. and Acquaah-Mensah, G.K. () Subcellular location and molecular mobility of human sulfotransferase SULT1C1 in living human embryonic kidney 293 cells. Drug Metabolism and Disposition 36:1-4.
Kapoor, R. and S heng, J.J. () Transfection of human CA-HPV-10 cells with sulfotransferase SULT1E1 affects estrogen signaling and gene expression. Drug Metabolism and Disposition 36:316-21.
Kapoor, R., Nimmagadda, D. and Sheng, J.J. () Cellular localization studies on human estrogen sulfotransferase SULT1E1 in human embryonic kidney 293 cells. Drug Metabolism and Disposition 35:17-20.
S heng, J.J., Saxena, A. and Duffel, M.W. () Influence of phenylalanines 77 and 138 on the stereospecificity of aryl sulfotransferase IV. Drug Metabolism and Disposition 32:559- 565.
S heng, J.J., and Duffel, M.W. () Enantioselectivity of human hydroxysteroid (alcohol) sulfotransferase ST2A3 (SULT2A1) for 1-naphthyl-1-ethanol, a model 1-arylethanol. Drug Metabolism and Disposition 31:697-700.
Shibutani, , Ravindernath, A., Terashima, I., Suzuki, N., Laxmi, Y.R.S., Kanno, Y., Suzuki, M., Apak, T.I., S heng, J.J., and Duffel, M.W. () Mechanism of lower genotoxicity of toremifene compared with tamoxifen. Cancer Research 61:-.
S heng, J.J., Sharma, V, and Duffel, M.W. () Measurement of aryl and alcohol sulfotransferase activity. Current Protocols in Toxicology 1:4.5.1-4.5.9. John Wiley & Sons, Inc., New
S heng, J.J., and Duffel, M.W. () Bacterial expression, purification, and characterization of rat hydroxysteroid sulfotransferase STa.Protein Expression and Purification 21:235-242.
S heng, , Hua, Z., Guo, J., Cagganna, M., and Ding, X. () Identification of a new human CYP2A gene fragment with close linkage to CYP2GP1. Drug Metabolism and Disposition 29:4-7.
S heng, J.,Guo, J., Hua, Z., Cagganna, M., and Ding, X. () Characterization of human CYP2G genes: widespread loss-of-functional mutations and genetic polymorphism. Pharmacogenetics 10:667-678.
Su, , Sheng, J.,Lipinskas, T.W., and Ding, X. () Expression of P450 2A genes in rodent and human olfactory mucosa. Drug Metabolism and Disposition 24:884-890.
S heng, J., and Ding, X. () Identification of human genes related to olfactory-specific CYP2G1. Biophy. Res. Com. 218:570-574.
Ding, X., Spink, D.C., Bhama, J.K., Sheng, J., Vaz, N.D., and Coon, M. J. () Metabolic activation of a potent olfactory-specific toxicant, 2,6-dichlorobenzonitrile (DCBN), an olfactory-Specific toxicant, by rat, rabbit, and human cytochrome P450: role of 2A and 2E isoforms. Pharmacology 49:-.
Kittel, M., S heng, J., Sellinger, O., and Domino, E.F. () Effects of MK-801 and PCP on rat brain cortical respiratory metabolism. Pharmacology Communications 4:258-261.
Domino, E.F., Yao, L.K., Sheng, J., Grekin, R.J., and Malvin, R.L. () Is nitric oxide involved in mediating rat open field behavior? Pharmacology Communications 3:175-178.
Domino, E.F., and Sheng, J. () N-methyl-D-aspartate receptor antagonist and dopamine D1 and D2 agonist interactions in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine induced hemiparkinsonian monkeys. Pharmacol. Exp. Ther. 264:221-225.
Domino, E.F., and Sheng, J. () Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys. Pharmacol. Exp. Ther.265:-.
El Karib, A.O., Sheng, J., Betz, A.L., and Malvin, R.L. () The central effects of a nitric oxide synthase inhibitor (N-nitro-L-arginine) in blood pressure and plasma renin. Exper. Hypertension 15:819-822.
ABSTRACTS AT NATIONAL AND INTERNATIONAL MEETINGS
Lu, S., Li, L., S heng, J., Spink, D. and Aldous, K. Comparison of Untargeted Methods using GC-MS and LC-TOF-MS/MS for Analysis of K2/Spice Synthetic Cannabinoids in Herbal US MSACL (The Association for Mass Spectrometry Applications to the Clinical Lab), Palm Springs, CA.
Ding , S heng, J.J, Wang, Y, Kluetzman K, Zhang Q.Y., and Turesky, R.J. () Transgenic Mouse Development for Studying Human Serum Albumin as a Biomarker of Carcinogenic Exposure. Experimental Biology / American Society for Pharmacology and Experimental Therapeutics, San Diego, CA.
Paul, P. Suwan, J. Sheng, J.J.Linhardt, R.J. Dordick, J. Liu, J. () Assays for enzymes used in the chemoenzymatic synthesis of heparin American Chemistry Society 243rd National Meeting, Philadelphia,
Paul, P. Suwan, J. Sheng, J.J.Linhardt, R.J. Dordick, J. Liu, J. () Assays for enzymes used in the chemoenzymatic synthesis of heparin American Institute of Chemical Engineers (AIChE) Annual Meeting , Pittsburgh,
Kapoor, and S heng, J. () Studies on the regulatory roles of human estrogen sulfotransferase SULT1E1 in the expression of signal transduction-related genes in human prostate cancer CA-HPV-10 cells. Experimental Biology /American Society for Pharmacology and Experimental Therapeutics, San Diego, CA.
Kapoor, and Sheng, J. () DNA microarray analysis suggests a regulatory role of human estrogen sulfotransferase SULT1E1 in the expression of signal transduction-related genes in human prostate cancer CA-HPV-10 cells. Experimental Biology / American Society for Pharmacology and Experimental Therapeutics, Washington DC.
Nimmagadda, D. and Sheng, J. () Immunochemical characterization of human sulfotransferase SULT1E1 in HEK293 cells. Poster presented at Experimental Biology / American Society for Pharmacology and Experimental Therapeutics, San Francisco,
Nimmagadda, D., Greiff, A., Gustad, T., and Sheng, J.J. () Overexpression of hydroxysteroid sulfotransferase SULT2A1 enhances the cytotoxicity of N-hydroxy-2- acetylaminofluorene in human embryonic kidney 293 cells. Poster presented at Experimental Biology /American Society for Pharmacology and Experimental Therapeutics, San Diego, CA.
Greiff, H. and Sheng, J.J. () Quantitative analysis of gene expression of hydroxysteroid/ alcohol sulfotransferase (SULT2A1) and estrogen sulfotransferase (SULT1E1) in normal and malignant human prostate cell lines.Poster presentation at Experimental Biology / American Society for Pharmacology and Experimental Therapeutics, Washington, DC.
S heng, J. J., and Duffel, M. W. () Enantioselectivity of human hydroxysteroid (alcohol) sulfotransferase ST2A3 for 1-naphthyl-1-ethanol, a model 1-arylethanol. 16th World Congress of Pharmacology, San Francisco,
S heng, J. J., Saxena, A., Sharma, V., and Duffel, M. W. () Studies on the molecular basis for the stereoselectivity of rat aryl sulfotransferase IV (ST1A1). Poster presentation at Experimental Biology /American Society for Pharmacology and Experimental Therapeutics, New Orleans,
S heng, J. J., and Duffel, M. W. () Expression, rapid purification, and stereoselectivity of recombinant hydroxysteroid sulfotransferase STa (ST2A2). 10th International Society for the Studies of Xenobiotics (ISSX) North American Meeting, Indianapolis,
S heng, J., Hua, Z, and Ding, X. () Cloning and characterization of a human nasal cDNA related to olfactory-specific CYP2G1. 36th Society of Toxicology Annual Meeting, Cincinnati, OH.
Ding, X., Spink, D. C., Bhama, J. K., Sheng, J., Vaz, N. D., and Coon, M. J. () Metabolic activation of a potent olfactory-specific toxicant, 2,6-dichlorobenzonitrile (DCBN), an olfactory-Specific toxicant, by rat, rabbit, and human cytochrome P450: role of 2A and 2E Experimental Biology /American Society for Biochemistry and Molecular Biology, Washington, DC.
Dr. G.S. Shankar
Professor, Clinical and Administrative Sciences
Bio
Dr. G.S. Shankar Completed his PharmD from Creighton University, Omaha, Nebraska, Master of Science degree from UNC in Public Health, completed Master of Clinical psychology from Calsouthern University and is a PsyD candidate from the same university. He is a registered pharmacist in the state of California and licensed as Advanced Practice Pharmacist as well from the state Board of Pharmacy. He is Fellow of the Australian College of Pharmacy (FACP) and fellows of the Australian college tend to have had training and certification in two clinical specialties and Dr. Shankar completed training and certifications in psychiatry and Geriatrics at the time of the fellowship award. He completed two years of training as a Pharmacist clinician and licensed as pharmacist clinician from New Mexico Board of pharmacy up to .
Recently he completed 5 years of experience as Clinical Pharmacy Specialist-Psychiatry at Veteran’s Out-patient’s Clinic with prescribing privileges at Laredo, Texas. Prior to this he worked as Associate Professor at Western University of Health Sciences, Pomona, California for a period of 13 years and also conducted a successful Psychopharmacology residency program. Prior to his teaching assignment, he worked as treatment review consultant to the department of mental health at Vacaville.
Education
PharmD – Creighton. University, NE
PSY.D (c) – California Southern University, CA
MS (Clinical Psychology) – California Southern University, CA
MS (Public Health) – University of Northern Colorado, CO
Pharm Clinician Training Ph-C Licensure (2 years) at CMF and Psychiatry at MH
Department, Vacaville. Currently licensed as Advanced Practice Pharmacist (CA).
Areas of Expertise: Ambulatory, In-Patient Care, Psychiatry and Neurology, and Clinical Psychology
Courses Taught: Psychiatry and Neurology and Clinical Psychology (for allied professionals)
Scholarship Interests: Research in Psychiatry and Psychology
Publications:
https://www.researchgate.net/profile/Gollapudi_Shankar/contributions
Article Publications
1. Mehgan Hassanzadah, Adib H. Bitar, Nile M. Khanfar, Fadi T. Khasawne, Kabirullah Lutfy, and Gollapudi S. Shankar, *A Retrospective Cohort Study of the Prevalence of Anxiety and Agitation in Schizophrenic Smokers and the Unmet Needs of Smoking Cessation Programs. Journal of Medicine (Dec )
2. Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside-A Book Chapter for Publication -Progress in Molecular Biology and Translational Research, , Elsevier Series (Sept )
3. Shankar GS () Role of Autacoids in the Development of Vulnerability and Resilience in Patients with Posttraumatic Stress Disorder (PTSD). J Autacoids 4: e126. doi:10./-.e126
4. Khasawneh F and Shankar G, (), Minimizing Cardiovascular Adverse Effects of Atypical Antipsychotic Drugs in Patients with Schizophrenia. Cardiology Research and Practice
5. GS Shankar () Serotonergic Projections: Religiosity and Hyper-Religiosity. J Autacoids 3: e123. doi:10./-.e123
6. Shankar GS, Yuan C () Effects of 5HT2c Blockade of Dibenzodiazepines on Thyroid Levels in Patients with Schizophrenia or Schizoaffective Disorder. J Autacoids 2: 102. doi:10./-.
7. Shankar G () Role of Serotonin from Thought and Anxiety to Weight Gain and Metabolic Syndrome. J Autacoids 1:e118. doi:10./.e118
8. Nazer L, Al-Najjar T, Shankar G, “Agranulocytosis Associated with Psychotropic Medications: A Fatal Case”- Literature Survey ‘Journal of American Society of Hospital Pharmacy’ published in July
9. Shankar G. “Clinical Assessment of Substance Abuse” Clinical Knowledge, Research and Therapeutics section, Spring California Pharmacist
10. Shankar G. ‘Conundrum of Bipolar Depression’, California Journal of Hospital Pharmacy May/June ; 18-23.
11. Shankar G, Nate C. “Positive and Negative Syndrome Scale as a long- term outcome measurement tool in patients receiving clozapine ODT- a Pilot Study”. Pharmacy Practice ; 5(1): 42-45.
12. Shankar G, Kelly Lee, Jack Chen. Metabolic Adverse Effects of Atypical Antipsychotic Medications. California Pharmacist Spring ; 12-17.
13. Jun JK, Shankar G, Shapiro K. The Pharmacology of Pain. California Pharmacist ; XLX (3):
Book Chapters
1. Shankar, G and Lutfy, K. Molecular Basis of Neuropsychiatric Disorders: from Bench to Bedside-A Book Chapter for Publication -Progress in Molecular Biology and Translational Research, , Elsiever Series (Sept )
2. Shankar G. “Clinical Psychopharmacology in Correctional settings”, Book: Correctional Mental Health- from Theory to Best Practice, , SAGE Publications, Inc
3. Shankar, G. “Practical Psychopharmacology: What every mental health professional needs to know – Manual for Mental Health Professionals”, Pesi HealthCare.
4. Shankar G, Kelly Lee, Jack Chen. “Metabolic, Endocrinology, and Cardiovascular Adverse Effects of Psychotropic Drugs”, Psychiatry, PSAP Program, Fifth Edition , Volume 3, 163-182
Non-Peer Reviewed
1. Shankar and Yuan, . Monitoring and Counseling of Metabolic Complications and Antipsychotic Pharmacotherapy; Premier Educational Solutions
2. Shankar, . Efficacy of Polypharmacy with Atypical Antipsychotic Medications in Schizoaffective Patients, Prescription Times
Arjun Dutta, PhD
Dean, School of Pharmacy
Education
PhD in Pharmacy Administration from the Medical College of Virginia, Virginia Commonwealth University
BS degree in Pharmacy from Jadavpur University in India
Bio
Dr. Arjun Dutta holds a BS degree in Pharmacy from Jadavpur University in India. He then completed his PhD in Pharmacy Administration from the Medical College of Virginia, Virginia Commonwealth University. Dr. Dutta specializes in Outcomes Research including the areas of Pharmacoeconomics, Quality of Life, and Epidemiology. Dr. Dutta has published extensively in Pharmacy Education including assessment of the curriculum, student admissions criteria, progression, and retention. Dr. Dutta has been involved in academic pharmacy for the past 22 years and has successfully started three pharmacy programs as a founding administrator in Oregon, New York, and California. His decanal appointments (over 12 years of administrative experience) include serving as the Interim Dean as well as Sr. Associate/Assistant Dean for Academic & Student Affairs at three new colleges of pharmacy. Prior to joining academia, he was an Outcomes Manager at a health economics firm specializing in Phase IV research for pharmaceutical companies. Dr. Dutta has over 71 publications in the form of research articles, abstracts, and book chapters in various peer-reviewed journals and professional meetings. He has received both federal (AHRQ, HRSA) and private funding and has conducted research in the areas of health services and outcomes assessment. Dr. Dutta has also been invited to speak at both national and international meetings.
Arjun enjoys travelling with his wife and two sons and is an avid reader and NFL-fan. He and his wife used to regularly compete in Ballroom Dance competitions.
Publications
1. Islam MA., Talukdar RM., Taheri R., and Dutta A. (), “Pharmacy relative to other Health Professionals in IPE: A Bibliometric Study.” Journal of
National Black Nurses Association: JNBNA, 30 Nov. , 30(2):38-43.
2. Lakhman S and Dutta A. (), “Endocrine Disruptive Chemicals: Silent poison for human health.” EC Pharmacology and Toxicology. 7.11 (): 62-63.
3. Dutta A. () The need to integrate Public Health courses in Health Professions curriculum. [Letter]. JOJ Pub Health 2(1): JOJPH.MS.ID. (). Available at: https://juniperpublishers.com/jojph/pdf/JOJPH.MS.ID..pdf
4. Dutta A. () Strategies to Improve Student Learning of Pharmacology in Pharmacy Curriculum. Pharm Pharmacol Int J 4(3): . DOI: 10./ppij..04. Available at: http://medcraveonline.com/PPIJ/PPIJ-04-.pdf
5. Chen JJ, Horne KE, Dutta AP () “Faith-Based Colleges and Schools of Pharmacy in the United States: A Taxonomic Survey and Results.” Pharm Pharmacol Int J 2(2): . DOI: 10./ppij..02.. Available at: http://medcraveonline.com/PPIJ/PPIJ-02-.pdf
6. Addo-Atuah J., Dutta A., Kovera C. (), “A Global health Elective Course in a Pharm.D. Curriculum.” American Journal of Pharmaceutical Education: ; Volume 78, Issue 10, Article 187. Available online at: http://www.ajpe.org/doi/full/10./ajpe Accessed February 4, .
7. Miederhoff P., Dutta A., Koomer A. (), “The Fungal Meningitis Tragedy: Implications for Pharmacy Education and the Profession.” [Letter]. American Journal of Pharmaceutical Education: ; Volume 77, Issue 1, Article 18. Available online at: http://www.ajpe.org/doi/full/10./ajpe Accessed February 14, .
8. St. Onge E., Suda K., Devaud L., Wilson A., Dutta A., Et al. Approaches to Management of Dilemmas by Leaders in Academic Pharmacy. Currents in Pharmacy Teaching and Learning. Apr. : V4 (2):78-83e2.http://www.sciencedirect.com/science/article/pii/SX. Accessed March 30, .
9. Dutta A. (), “Is There a Need for More Research-based Courses in the PharmD Curriculum?” [Letter]. American Journal of Pharmaceutical Education ; 75(5); Article 102. Available online at: http://www.ajpe.org/view.asp?art=aj&pdf=yes
10. Koomer A., Lourdes M., Coronel C., Dutta A., Et. al. A pilot study highlighting differences in pharmacists’ perceptions regarding use of pharamcogenetic information in their profession. Journal of Pharmaceutical Research and Health Care (JPRHC) ; Vol. 3, Issue 2: 50-61. http://www.jprhc.in/files/.pdf
11. Dutta A., Koomer A. (), Survey of new pharmacy schools: insights on structure and planning. Journal of Pharmaceutical Research. :10(1): 34-41.
http://journalofpharmaceuticalresearch.org/index.php/kpc/article/view/. Accessed: March 31, .
12. Dutta A. (), “Change of the Guard- Are we ready?” [Letter]. American Journal of Pharmaceutical Education ; 74(1); Article 16. Available online at: http://www.ajpe.org/view.asp?art=aj&pdf=yes&w=n
13. Hailemeskel B., Dutta A., Daftary M, Oluwaranti A, Ayuk-Egbe P, Koomer A, Ellis L et al. A Campus-Community Pharmacy Partnership to Foster Awareness and Utilization of MedlinePlusJournal of American Pharmacists Association May-June ; 47(3): 385-389.
14. Ghilzai NK, Dutta A. (), “India to Introduce 5-year Doctor of Pharmacy Program” [Letter]. American Journal of Pharmaceutical Education ; 71(2); Article 38. Available online at: http://www.ajpe.org/aj/aj/aj.pdf
15. Hailemeskel B., Dutta A., Olagbaju F., Ifelowo O., Koomer A. Demographic Differences and Drug Information Resource Preferences of U.S. Pharmacists. Journal of Pharmaceutical Research. Oct. ; Vol.5, No. 4: 104-107.
16. Hailemeskel B., Dutta A., (), Daftary M., Ayuk P., Et. al. Relationship between pharmacy technician experience and academic performance- A pilot project. Journal of Pharmaceutical Research. July ; Vol.5, No. 3: 65-68.
17. Koomer A., Dutta A., Et. Al. To Grade or Not To Grade: Moving away from Grades. U.S. Pharmacist Student Edition Winter :5-7.
18. Dutta A., (), A commentary on stress research in the US. International Journal of Therapy and Rehabilitation. March ; v13 (3): 117.
19. Hailemeskel B., Dutta A., and Rose D. (), Drug Interactions-Knowledge and attitudes of Hospital Pharmacists. Journal of Pharmaceutical Research. January ; Vol. 5, No. 1: 1-5.
20. Dutta A., Oke F., Daftary M., Et al. Geriatric Education in US Schools of Pharmacy. Consultant Pharmacist. ; 20(1): 45-51.
21. Dutta A., Pyles M, and Miederhoff P. Stress in Health Professions Students. Journal of National Black Nurses Association. July ; 16(1):63-68.
22. Reddy R, Daftary MN, Delapenha RD, Dutta AP, Oliver J, Frederick W., Avascular Necrosis and Protease Inhibitor Therapy: 3 Cases. Journal of the National Medical Association ; 97(11): -.
23. Montague M., Nichols S., Dutta A. (), Self-Management in African-American women with diabetes. The Diabetes Educator. ; v31n5: 700-710.
24. Sansgiry S., Bhosle M., Dutta, A. Predictors of test anxiety in doctor of pharmacy students: An empirical study. Pharmacy Education. June ; v5(2):121-129. Available online at: http://journalsonline.tandf.co.uk/app/home/contribution.asp?wasp=b2afbafcd2&referrer=parent&backto=issue,7,11;journal,1,17;linkingpublicationresults,1:,1
25. Wutoh A., Dutta A., et al. Treatment perceptions and attitudes of older HIV-infected adults. Research in Social and Administrative Pharmacy. ; 1:60-76.
26. Calrke-Taker V. and Dutta A. African-American men and their reflections and thoughts on Prostate Cancer. Journal of National Black Nurses Assoc. July ; 16(1):1-7.
27. Dutta A. (), “The FPGEE Curriculum Requirement: An Insurmountable Hurdle?” [Letter]. American Journal of Pharmaceutical Education ; 69(5); Article 105. Available online at: http://www.ajpe.org/aj/aj/ajpe105.pdf
28. Sansgiry S., Dutta, A., Et al. Predictors of Academic Performance at Two Diverse Universities: Effect of Academic Progression. AJPE. Oct. ; 68(4); Article 103. Available online at: http://www.ajpe.org/view.asp?art=aj&pdf=yes
29. Shields K., Dutta A, Daftary M., Et al. NP and CAM education in the US pharmacy schools-Results & Comparisons of two surveys. Journal of Pharmacy Teaching. ; 11(2):1-12.
30. Hailemeskel B, Bullard W, Ayuk-Egbe P, Daftary M, Akiyode O, Dutta A, Bernard D, Olusanya O, Keeys C, and Bwayo S. (), Selected non-approved use of recombinant human erythropoietin. Part 2 of 2. Advances in Pharmacy. ; 2(3):280-288.
31. Bullard W, Hailemeskel B, Ayuk-Egbe P, Daftary M, Akiyode O, Dutta A, Bernard D, Belrhiti S, Eze G, and Keeys C. (), Selected non-approved use of recombinant human erythropoietin. Part 1 of 2. Advances in Pharmacy. ; 2(2):146-155.
32. Dutta A. In response to the letter entitled, “Pharmacy Graduates from Foreign Countries Flooding US Job Market” [Letter]. AJPE ; 68(1), Article 23. Available online at: http://www.ajpe.org/view.asp?art=aj&pdf=yes
33. Dutta A., Miederhoff P, and Pyles M. (), Complementary & Alternative Medicine Education: Students’ Perspectives. American Journal of Pharmaceutical Education. ; 67(2), Article 46. Available online at: http://www.ajpe.org/volsIssues/issueView.asp?vol=67&issue=02
34. Daftary M., Dutta A., Lee E., Olagundoye A., and Xue Z. Patients’ willingness to pay for cognitive pharmacy services in ambulatory care settings in the US. Journal of Pharmacy Practice and Research. (December); 33: 265-7.
35. Dutta A., Bwayo S, Xue X, Et al. Complementary and Alternative Medicine Instruction in Nursing Curricula. Journal of National Black Nurses Association. Dec. ; 14(2):30-33.
36. Dutta A., Daftary M., Ayuk P., and Kang H. State of CAM Education in US Schools of Pharmacy: Results of a National Survey. JAPhA. Jan-Feb. ; 43(1):81-83.
37. Bernard D., Dutta A., Daftary M. A descriptive report of bleeding complications secondary to Warfarin Therapy. Hospital Pharmacy ; 38(1):36-39
38. Hailemeskel B., Dutta A., and Daftary M. SIAR in a university teaching hospital. American Journal of Health-System Pharmacy Jan. ; vol. 60:194-195.
39. Dutta A., Wutoh A., Williams C., and Ofosu J. Predictors of Academic Success at a Historically Black School of Pharmacy. Journal of Pharmacy Teaching ; 10(2): 1-14.
40. Dutta A. In response to the letter entitled, “Doctoral Education: A tragedy of the commons” [Letter]. Am. J. Pharmaceutical Education ; 66(4):463-464.
41. Hailemeskel B. and Dutta A. A Review of Internet Based Drug Information Resources and Student Preferences. Journal of Social and Administrative Pharmacy. ; 19(3):82-86.
42. Hailemeskel B, Ayuk-Egbe P, Akiyode O, Dutta A., Olu Ifelowa, Betton T, Kim M, Dillon E, and Fullas F. The effect of Pharmacist’s Herbal Counseling on Patients’ Knowledge and Satisfaction in a Community Pharmacy. Natural Health Partner; :1(15) (On-line Journal) http://www.imakenews.com/entrails/e_article.cfm
43. Hailemeskel B., Dutta A, Wutoh A., Adverse Reactions and Interactions among Herbal Users. Issues in Interdisciplinary Care, National Academies of Practice, Oct. ; V3N4:297-300.
Sukhwinder S. Lakhman, PhD
Associate Professor of Pharmaceutical Science
Education
B.Sc. (Medical), B.Ed., M.Sc. (Life Sciences), M.Phil. (Neuropharmacology), Ph.D. (Neurosciences) Guru Nanak Dev University, Amritsar, Punjab, India.
Bio
Dr. Lakhman has more than 15 years of experience in academic, research and teaching in different schools of pharmacy. After earning his Ph. D. degree from Guru Nanak Dev University, he started working as postdoctoral fellow and later as Instructor/ Research Scientist in the State University of New York (SUNY) at Buffalo School of Pharmacy and Pharmaceutical Sciences. During his tenure at SUNY Buffalo he worked in different areas of Pharmaceutical Sciences. He has also worked in and was a founding faculty of D’Youville College School of Pharmacy prior to joining American University of Health Sciences.
He is reviewer of various peer review Journals such a Pharmacogenomics, Pharmaceutical Research, Biogerontology, etc. He has research expertise in the various area such as Pharmacokinetic, Pharmacodynamics, Molecular Pharmacology and Pharmacogenomics as is apparent from his peer reviewed publications. And has published more than 25 research articles in prestigious journals like Pharmacogenomics, Molecular Pharmacology, Journal of Biological Chemistry, Drug metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, Brain research etc. He extends is role beyond teacher to serve as volunteer member in Clean air Coalition, Worked as volunteer in a soap kitchen- “Friends of the Night”, Volunteer in the Great Lakes Consortium etc.
Published Research
Kaur , T., Manchanda, S., Lakhman, S.S. and Kaur, G. (). Efficacy of anti-epileptic drugs in treatment of Tumor and its associated Epilepsy: An in vitro Perspective. Annals of Neurosciences 23 (1): 33-43.
Singh,R., Lakhanpa, D., Manchanda, S., Kuma, S., Kaur,T., Lakhman, S.S. and Kaur, G. (). Middle age on set short-term intermittent fasting dietary restriction prevents brain function impairments. Biogerontology 16(6) : 775 – 88.
Kaur, G. and Lakhman, S. (). Dietary restrictions as a potential intervention to retard age-associated impairments of brain functions. This is in: Thakur, M.K. and Rattan, S.I.S (ed’s) Brain Aging and Therapeutic Interventions, New York, NY. Springer Press.
Lakhman, S. S., Ma, Qing and Morse, G.D., (). Pharmacogenomics of CYP3A: Considerations for Human Immunodeficiency Virus Treatment. (Review article) Pharmacogenomics (Future medicine) 10(8):- .
Lakhman, S. S. Chen, X., Gonzalez, V.M., Schuetz, E. G and Blanco, J.G. () Functional characterization of the promoter of human carbonyl reductase 1 (CBR1). Role of XRE elements in mediating the induction of CBR1 by ligands of the aryl hydrocarbon receptor. Molecular Pharmacology 72(3): 734-43.
Gonzalez, V.M., Ghosh, D., Lakhman, S. S., Pendyala, L., and Blanco, J.G. (). A functional genetic polymorphism on human carbonyl reductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH binding affinity. Drug Metabolism Disposition 35(6):973-80.
Gonzalez, V.M., Lakhman, S. S., Ghosh, D., Pendyala, L., and Blanco, J.G. (). Functional characterization of a Non-synonymous Single Nucleotide Polymorphism in Human carbonyl Reductase 1 CBR1V88I). AAPS Pharm Sc, 8(S2):.
Gonzalez, V.M., Lakhman, S. S., Forrest, A., Relling, M. V., and Blanco, J.G. (). Higher activity of polymorphic NAD(P)H:Quinone oxidoreductase in liver cytosols from blacks compared to whites. Toxicology Letters 164: 249-258.
Lakhman, S. S, Ghosh, D and Blanco, J.G., (). Functional Significance of a Natural Allelic Variant of Human Carbonyl Reductase 3 (CBR3). Drug Metabolism Disposition 33(2):254-257.
Bhattacharya, A., Lakhman, S.S. and Singh, S. (). Modulation of L-type calcium channels in Drosophila by Pituitary adenylyl cyclase-activating Polypeptide (PACAP) mediated Pathway. J. Biological Chemistry 279 (36)3:-.
Chandrasekaran, E.V.,Lakhman, S. S., Chawda, R., Piskorz, C.F., Neelamegham, S and Matta,K.L., () Identification of Physiologically Relevant Substrates for cloned Gal: 3-O-Sulfotransferases (Gal3STs) distinct high affinity of Gal3ST-2 and LS180, sulfotransferase for the GLOBO H backbone, Gal3ST-3 for N-Glycan MULTITERMINAL Galβ1,4GlcNAcβ units and 6- SULFO Galβ1,4GlcNAcβ,and Gal3ST-4 for the mucin core-2 Trisaccharide. J. Biological Chemistry 279 (11): -.
Suhui Yang, PhD
Assistant Professor of Pharmaceutical Sciences
Education
B.S., Oceanography (Major) and Chemistry (Minor), Pukyong National University, South Korea
M.S., Marine Chemistry, Stony Brook University, New York
Ph.D., Medicinal Chemistry, Chonnam National University, South Korea
Bio
Dr. Suhui Yang obtained her B.S. in Oceanography (major) and Chemistry (minor) from Pukyong National University, South Korea, in and her M.S. in Marine Chemistry from Stony Brook University, New York, in . She later switched her interest to Medicinal Chemistry and earned her Ph.D. under the guidance of Prof. Won-Jea Cho from Chonnam National University, South Korea, in . Her doctoral research was focused on the design and development of novel small molecule compounds targeting Androgen Receptor, Topoisomerase, or JAK/STAT pathway for treating cancers. In research, she used to apply computational techniques such as virtual screening or molecular docking, synthesize various chemical libraries, and optimize the active compounds.
Dr. Yang moved to the University of Michigan where she conducted research as postdoctoral fellow with Prof. Nouri Neamati, working on synthesis of bioactive small molecule compounds as anti-cancer agents (-). Dr. Yang joined the faculty of the American University of Health Sciences as an Assistant Professor of Pharmaceutical Sciences, School of Pharmacy, in August . Her current research interests are the design and development of small molecule compounds as chemotherapeutic agents and the use of photoaffinity probes for identification of the molecular targets of small molecules.
Selected Publications
1. J. Han, HW. Lee, Y. Jin, DB. Khadka, S. Yang, X. Li, M. Kim, WJ. Cho, “Molecular design, synthesis, and biological evaluation of bisamide derivatives as cyclophilin A inhibitors for HCV treatment”, Eur. J, Med. Chem., (), 188, .
2. S. Xu, Y. Liu, K. Yang, H. Wang, A. Shergalis, A. Kyani, A. Bankhead, S. Tamura, S. Yang, X. Wang, C. Wang, A. Rehemtulla, M. Ljungman, N. Neamati, “Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes”, Theranostics, (), 9, .
3. S. Yang, A. Shergalis, D. Lu, A. Kyani, Z. Lu, M. Ljungman, N. Neamati, “Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors”, J. Med. Chem., (), 62, .
4. A. Kyani, S. Tamura, S. Yang (co-first), A. Shergalis, S. Samanta, Y. Kuang, M. Ljungman, N. Neamati, “Discovery and Mechanistic Elucidation of a Class of Protein Disulfide Isomerase Inhibitors for the Treatment of Glioblastoma”, Chem. Med. Chem., (), 13, 164.
5. K. Ramkumar, S. Samanta, A. Kyani, S. Yang, S. Tamura, L. Ziemke, J. Stuckey, S. Li, K. Chinnaswamy, H. Otake, B. Debnath, V. Yarovenko, J. Sebolt-Leopold, M. Ljungman, N. Neamati, “Mechanistic evaluation and transcriptional signature of a Glutathione S-transferase Omega 1 inhibitor”, Nature Comm., (), 7, .
6. S. Yang, J. K. R., S. Lim, T. G. Choi, J.-H. Kim, S. Akter, M. Jang, H.-J. Ahn, H.-Y. Kim, M. P. Windisch, D. B. Khadka, C. Zhao, Y. Jin, I. Kang, J. Ha, B.-C. Oh, M. Kim, S. S. Kim, W.-J. Cho, “Structure-Based Discovery of Novel Cyclophilin A Inhibitors for the Treatment of Hepatitis C Virus Infections”, J. Med. Chem., (), 58 (24), -.
7. C. Zhao, S. H. Yang, D. B. Khadka, Y. Jin, K.T. Lee, W.-J. Cho, “Computer-aided discovery of aminopyridines as novel JAK2 inhibitors”, Bioorg. Med. Chem., (), 23, 985-995.
8. D. B. Khadka, H. Woo, S. H. Yang, C. Zhao, Y. Jin, T. N. Le, Y. Kwon, W.-J. Cho, “Modification of 3-arylisoquinolines into 3,4-diarylisoquinolines and assessment of their cytotoxicity and topoisomerase inhibition”, Eur. J, Med. Chem., (), 92, 583-607.
9. H. T. M. Van, H. M. Jeong, D. B. Khadka, S. H. Yang, C. Zhao, Y. Jin, K. Y. Lee, Y. Kwon, W.-J. Cho, “Design, synthesis and systematic evaluation of cytotoxic 3-heteroarylisoquinolinamines as topoisomerases inhibitors”, Eur. J, Med. Chem., (), 82, 181-194.
10. Y. Jin, D. B. Khadka, S. H. Yang, C. Zhao, W.-J. Cho, “Synthesis of novel 5-oxaprotoberberines as bioisosteres of protoberberines”, Tetrahedron Lett., (), 55, -.
11. S. H. Yang, C.-H. Song, H. T. M. Van, E. Park, D. B. Khadka, E.-Y. Gong, K. Lee, and W.-J. Cho, “SAR Based Design of Nicotinamides as a Novel Class of Androgen Receptor Antagonists for Prostate Cancer”, J. Med. Chem., (), 56 (8), -.
12. C.-H. Song, S. H. Yang (co-first), E. Park, S. H. Cho, Eun-Yeung Gong, D. B. Khadka, W.-J. Cho, and K. Lee, “Structure-Based Virtual Screening and Identification of a Novel AR Antagonist”, J. Biol. Chem., (), 287 (36), -.
13. T. N. Le, S. H. Yang (co-first), D. B. Khadka, S. H. Cho, C. Zhao, W.-J. Cho, “Synthetic approaches to natural antioxidant Benzastatin E, F and G analogues”, Bull. Korean Chem. Soc., (), 32 (12), -.
14. S. H. Yang, D. B. Khadka, S. H. Cho, H.-K. Ju, K. Y. Lee, K.-T. Lee, W.-J. Cho, “Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors”. Bioorg. Med. Chem., (), 19 (2), 968-977.
15. S. H. Yang, H. T. M. Van, T. N. Le, D. B. Khadka, S. H. Cho, K.-T. Lee, E.-S. Lee, Y. B. Lee, C.-H. Ahn, W.-J. Cho, “Development of 3-aryl-1-isoquinolinamines as potent antitumor agents based on CoMFA”, Eur. J. Med. Chem., (), 45 (11), -.
16. S. H. Yang, H. T. M. Van, T. N. Le, D. B. Khadka, S. H. Cho, K.-T. Lee, H.-J. Chung, S. K. Lee, C.-H. Ahn, Y. B. Lee, W.-J. Cho, “Synthesis, in vitro and in vivo evaluation of 3-arylisoquinolinamines as potent antitumor agents”, Bioorg. Med. Chem. Lett., (), 20 (17), -.
Mohammed A. Islam, PhD, RPh
Senior Associate Dean for Academic Affairs, Professor
Education
PhD and MPhil (Toyama University, Japan) and BS and MS in Pharmacy (University of Dhaka, Bangladesh)
Bio
Dr. Islam currently serves as the Senior Associate Dean of Academic Affairs and Professor of Pharmaceutical Sciences at the American University of Health Sciences (AUHS) School of Pharmacy. Dr. Islam has more than 20 years of academic research, teaching, pharmacy practice, and administrative experiences. Prior to joining AUHS in February , he served as Assistant Dean of Academic Affairs and Professor of Pharmacology at West Coast University School of Pharmacy.
Dr. Islam went to Toyama University in Japan where he earned MPhil and PhD degrees in Pharmaceutical Sciences. He earned his master’s and bachelor’s degrees in pharmacy from the University of Dhaka, Bangladesh.
Dr. Islam has extensive research experience with more than 30 peer-reviewed journal articles and 55 conference abstracts. His current research interests include pharmacy curriculum, global pharmacy education, and Scholarship of Teaching and Learning (SoTL). Dr. Islam’s research has been published in leading pharmacy education journals and presented at national and international conferences.
Published Research
• Islam MA, Taheri R, McBane S, Talukder R. Faculty assessment of scholarship of teaching and learning among United States pharmacy programs. Currents in Pharmacy Teaching and Learning (in press), .
• Rashid M, Rahman M, Nounou M, and Islam MA. Speed and accuracy of pharmacy students’ response to calculation problems with or without formula prompts. Currents in Pharmacy Teaching & Learning. (in press ).
• Islam MA, Bagheri R, Lung L, Park SY, Talukder R. Status of Teaching Certificate Programs Offered by US Colleges and Schools of Pharmacy. Health Professions Education. 6 (1): 105-114, . https://doi.org/10./j.hpe..04.001
• Islam MA, Talukder RM, Taheri R, Dutta A. Pharmacy Relative to Other Health Professions in Interprofessional Education: A Bibliometric Study. J Natl Black Nurses Assoc. 30(2):38-43, .
• Islam MA, Khan SA, Gunaseelan, S, Talukder R. Physician Perceptions of Integrating Pharmacists into Healthcare in Bangladesh. J Pharm Pract and Res (). https://doi.org/10./jppr.
• Islam MA, Sabnis G, Farris F. The trilayer approach of teaching physiology, pathophysiology, and pharmacology concepts in a first-year pharmacy course: the TLAT model. Adv Physiol Educ. Sep 1;41(3):395-404, .
• Islam MA, Talukder R, Taheri R, and Blanchard, N. Integration of basic and clinical science courses in US PharmD programs. Am J Pharm Educ. 80 (10) Article 166, .
• Islam MA, Khan SA, Talukder RM. Status of Physiology Education in US Doctor of Pharmacy programs. Adv Physiol Educ. Dec; 40(4):501-508,
• Islam MA, Chen G, and Talukder RM. Specialty Tracks in PharmD Curricula of US Colleges and Schools of Pharmacy. Currents in Pharmacy Teaching and Learning. 8(6):774-781, .
• Islam MA, Khan SA, Gunaseelan S, and Talukder RM. Specialty education for student pharmacists and PharmD graduates in US Colleges and Schools of Pharmacy. Currents in Pharmacy Teaching and Learning. 8:184-190,
• Islam MA and Schweiger TA. Students’ Perception of an Integrated Approach of Teaching Entire Sequence of Medicinal Chemistry, Pharmacology, and Pharmacotherapeutics Courses in PharmD Curriculum. Journal of Pharmacy Practice. 28(2):220-6, .
• Islam MA, Gunaseelan S, Talukder RM, Khan S. Current Challenges in Pharmacy Education in Bangladesh: A Roadmap for the Future. Currents in Pharmacy Teaching and Learning. 6:730–735, .
• Islam MA, Gunaseelan S, Khan SA. A Research Elective Course on Dietary Supplements to Engage PharmD Students in Primary Literature Evaluation and Scholarly Activity. Journal of Pharmacy Practice 1-8 DOI: 10./; .
• Islam MA, Schmidt RW, Gunaseelan S, Sanchez A. An Update on the Cardiovascular Effects of Quercetin, a Plant Flavonoid. Current Nutrition & Food Science 10:36-48, .
• Islam MA, Schmidt RW, Gunaseelan S, Sanchez A. An Update on the Cardiovascular Effects of Quercetin, a Plant Flavonoid. Current Nutrition & Food Science 10:36-48, .
• Islam MA. An Elective Course on the Basic and Clinical Sciences Aspects of Vitamins and Minerals. Am J Pharm Educ77: Article 17. .
• Downing L and Islam MA (corresponding author). The Use of Calcium Supplements and Cardiovascular Adverse Effects: An Update. Am J Health-Syst Pharm. 70:-, .
• Islam MA. Cardiovascular effects of green tea catechins: progress and promise. Recent Patents on Cardiovascular Drug Discovery 7: 88-99, .
• Islam MA. Soy Isoflavones and Cardiovascular Health: An Update. Current Nutrition and Food Science 7:108-121, .
• Islam MA. Pharmacological Modulations of Cardiac Ultra-rapid and Slowly Activating Delayed Rectifier Currents: Potential Antiarrhythmic Approaches. Recent Patents on Cardiovascular Drug Discovery, 5: 33-46, .
• DeSantiago J, Islam MA, Ziolo MT, Bers DM, and Pogwizd SM: Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are due to enhanced SR Ca load. Circulation Research,
• Despa S, Islam MA, Pogwizd SM, Bers DM: Intracellular [Na+] and Na+pump rate in rat and rabbit ventricular myocytes. J Physiol539: 133-143, .
• Despa S, Islam MA, Pogwizd SM, Bers DM: Intracellular Na+concentration is elevated in heart failure, but Na/K-pump function is unchanged. Circulation;105:-, .
• Kimura I, Islam MA, Ritsu H, Nojima H, Tezuka Y, and Zhao W: Blood pressure lowering, positive chronotropy and inotropy by the veratrum alkaloids germidine and germerine but negative chronotropy by veratridine in mice. J Asian Natural Product Research, 2: 133-144, .
• Islam MA, Nojima H, and Kimura I: Acetylcholne-induced biphasic effect on the maximum upstroke velocity of action potential in mouse isolated right atria: Interaction with b-adrenergic signaling cascade. Jpn J Pharmacol. 78: 181-190, .
• Islam MA, Nojima H, and Kimura I: Muscarinic M1receptor activation reducesmaximum upstroke velocity of action potential in mouse right atria. Eur J Pharmacol. 346: 227-236, .
• Chowdhury AKA, Islam MA, Rashid A, and Ferdous AJ: Therapeutic potential of the volatile oil of Nigellasativaseeds in monkey model with experimental shigellosis. Phytotherapy Res. 12: 361-363, .
• Kimura I, Islam MA, Nojima H, Mizumoto J, Tezuka Y, Weijie Z: Blood pressure-lowering, positive chronotropic and inotropic effects of the veratrum alkaloids, germidine and germerine in mouse. J of Traditional Medicines, 15: 254-255, .
• Kimura I, Islam MA, and Kimura M: Potentiation by higenamine of the aconitine induced positive chronotropic effect in isolated right atria of mice: The effects of cholera toxin, forskolin and pertussis toxin. Biol Pharm Bull. 19: -, .
• Kimura I, Islam MA, and Kimura M.: Cholera toxin accentuates the antagonism by acetylcholine of higenamine-induced positive chronotropy in isolated right atria of mice. Biol Pharm Bull. 18: -, .
• Kimura I, Makino M, Takamura Y, Islam MA, and Kimura M: Positive chronotropic and inotropic effects of higenamine and its enhancing action on the aconitine-induced tachyarrhythmia in isolated murine atria. Jpn J Pharmacol. 66: 75-80, .
• Kimura I, Hata Y, Islam MA, and Kimura M: Diabetes mellitus-induced enhancement of prostaglandin F2a-response is inhibited by lipoxygenase-but not cyclooxygenase-inhibitors in mesenteric veins and arteries of mouse and rat. Jpn J Pharmacol. 64: 65-70, .
• Reza S, Khan OF, Islam MA, Rashid A, and Chowdhury AKA: In vitro antibacterial activity of Ipomoea fistulusa. Fitoterapia LXV: 465-466, .
Sandor Szabo, MD, MSc, PhD, MPH, DSc (h.c.)
Professor of Pharmaceutical Sciences
Education
MD, University of Belgrade Medical School
MSc, University of Montreal Medical Faculty
PhD, University of Montreal Medical Faculty
MPH, Harvard School of Public Health
Bio
Sandor Szabo, a Fellow of the American Gastroenterological Association (AGAF), and an External Member of the Hungarian Academy of Sciences: After finishing medical school in Belgrade, obtained MSc & PhD in the institute of Hans Selye (the ‘father of biologic stress’) at the University of Montreal & continued with pathology residency at Harvard Med Sch, Boston, where he became assistant & associate professor. He also obtained an MPH at Harvard School of Public Health, & after 20 years at Harvard, became a professor of pathology & pharmacology at the Medical School of University of California, Irvine (UCI), CA. He also served as chief of Pathology & Laboratory Medicine Service for 20 years, of which for 12 years also covered the functions of chief of staff at the VA Medical Center in Long Beach, CA, where he continued his productive research in the molecular mechanisms of stress-related diseases, esp., gastrointestinal (GI) ulceration. His laboratory was the first to publish easily reproducible, chemically induced duodenal ulcers & adrenal necrosis in rats. This was followed by structure-activity studies (SAS) with chemicals that induce duodenal ulcers which is the most frequent form of peptic ulcers in patients. These SAS led to the first recognition of dopamine in the pathogenesis of duodenal ulceration in animal models & man. Subsequently, he demonstrated for the first time the potent ulcer healing effect of angiogenic growth factors which on molar basis 2-7 million times more potent than antisecretory or anti-H. pylori drugs. His laboratory also published the first gene expression & gene therapy results in duodenal ulceration.
So far, he has 235 original, peer-review publications (several in the best scientific journals like Nature, Science, PNAS, BBRC, JAMA, Lancet, J. Clin. Invest., Lab. Invest., Endocrinology, Gastroenterology, Am. J. Pathol., J. Pharm. Sci., J. Pharmacol. Exp. Ther.), 55 review articles, 37 book chapters, 5 books edited, & 241 invited lectures in North America, Europe, Asia & Australia as well as 9 approved patents, mostly for new GI ulcer drugs & one pending application. In teaching activities, he was course director for general pathology at Harvard Medical School & was teaching GI & endocrine pathology as well as courses in public health & toxicology at Harvard & UCI.
He was associate master at one of the 5 student academic societies at Harvard Medical School (i.e., at Peabody Society) & initiated the establishment of similar student academic societies at UCI to promote small-group teaching & flip classroom techniques. In he initiated the annual week-long international Summer Schools on Stress (https://www.stresseducation.org ) that has been held at various universities over the world, e.g., Hungary, Croatia, France, Slovakia, Japan & Russia.
Selected Publications
Selye H, Szabo S. Protection by various steroids against gold nephropathy. Eur. J. Toxicol. ; 4:512-516.
Szabo S, Selye H. Duodenal ulcers produced by propionitrile in rats. Arch. Pathol. ; 93:389-390.
Selye H, Szabo S, Kourounakis P. Protection against phenylisothiocyanate by various steroids, phenobarbital and diphenylhydantoin. J. Pharm. Pharmacol. ; 24:333-334.
Selye H, Szabo S. Experimental model for production of perforating duodenal ulcers by cysteamine in the rat. Nature ; 244:458-459.
Szabo S, Selye H, Kourounakis P, Taché Y. Comparative studies on the effect of adrenocorticotropic hormone (ACTH) and pregnenolone-16a-carbonitrile (PCN) upon drug response and distribution in rats. Biochem. Pharmacol. ; 23:-.
Kourounakis P, Szabo S, Selye H. Effect of various steroids and ACTH on the distribution of zoxazolamine in rats. J. Pharm. Sci. ; 62:-.
Szabo S, Kourounakis P, Selye H, Da Silva O. Pharmacodynamic interactions among gluco-, mineralo-, glucomineralocorticoids, pregnenolone-16a-carbonitrile and various drugs. J. Pharmacol. Exp. Ther. ; 188:45-54.
Szabo S, Komlos S, Ignjatovi_ Z. Effect of pregnenolone-16a-carbonitrile (PCN) on drug response in man. J. Pharm. Pharmacol. ; 27:113-118.
Szabo S, Kourounakis P, Selye H. Influence of adrenocorticotropic hormone, somatotrophic hormone and pregnenolone-16a-carbonitrile on drug response and metabolism. Biochem. Pharmacol. ; 24:-.
Szabo S, Reynolds ES, Kovacs K. Animal model of human disease. Waterhouse-Friderichsen syndrome. Animal model: acrylonitrile-induced adrenal apoplexy. Am. J. Pathol. ; 82:653-656.
Szabo S, Reynolds ES, Moslen MT. Chemical factors in aetiology of duodenal ulcer. Lancet ; 2:73.
Schwedes U, Usadel K, Szabo S. Somatostatin prevents cysteamine-induced duodenal ulcer. Eur. J. Pharmacol. ; 44:195-196.
Szabo S. Animal model of human disease. Duodenal ulcer disease. Animal model: cysteamine-induced acute and chronic duodenal ulcer in the rat. Am. J. Pathol. ; 93:273-276.
Szabo S, Bailey KA, Boor PJ, Jaeger RJ. Acrylonitrile and tissue glutathione: differential effect of acute and chronic interactions. Biochem. Biophys. Res. Commun. ; 79:32-37.
Szabo S, Horvath E, Kovacs K, Larsen PR. Pyrazole-induced thyroid necrosis: a distinct organ lesion. Science ; 199:-.
Szabo S. Dopamine disorder in duodenal ulceration. Lancet ; 2:880-882.
Szabo S, Hüttner I, Kovacs K, Horvath E, Szabo D, Horner HC. Pathogenesis of experimental adrenal hemorrhagic necrosis (“apoplexy”). Ultrastructural, biochemical, neuropharmacologic and blood coagulation studies with acrylonitrile in the rat. Lab. Invest. ; 42:533-546.
Szabo S, Trier JS, Frankel PW. Sulfhydryl compounds may mediate cytoprotection. Science ; 214:200-202.
Szabo S, Reichlin S. Somatostatin depletion in rat organs: a novel effect of the potent duodenal ulcerogen, cysteamine. Endocrinology ; 109:-.
Szabo S, Reynolds ES, Unger SH. Structure-activity relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis. J. Pharmacol. Exp. Ther. ; 223:68-76.
Palkovits M, Browstein MJ, Eiden LE, Beinfeld MC, Russell J, Arimura A, Szabo S. Selective depletion of somatostatin in rat brain by cysteamine. Brain Res. , 240, 178-180.
Adler RS, Gallagher GT, Szabo S. Duodenal ulcerogens cysteamine and propionitrile decrease duodenal neutralization of acid in the rat. Dig. Dis. Sci. ; 28:716-723.
Neumeyer JL, Szabo S. (-)-10,11-Methylenedioxy-N-propylnoraporphine, an orally effective dopamine agonist and duodenal antiulcerogen in the rat. Eur. J. Pharmacol. ; 88:273-274.
Gallagher GT, Szabo S. Direct measurement of duodenal acid-pepsin exposure at site of ulceration in rats. Am. J. Physiol. ; 246: G660-G665.
Szabo S, Gallagher G, Horner HC, Frankel PW, Underwood RH, Konturek SJ, Brzozowski T, Trier JS. Role of the adrenal cortex in gastric mucosal protection by prostaglandins, sulfhydryls and cimetidine in the rat. Gastroenterology ; 85:-.
Szabo S, Trier JS, Brown A, Schnoor J. Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat. Gastroenterology ; 88:228-236.
Pihan G, Kline TJ, Hollenberg NK, Szabo S. Duodenal ulcerogens cysteamine and propionitrile induce gastroduodenal motility alterations in the rat. Gastroenterology ; 88:989-997.
Crum R, Szabo S, Folkman J. A new class of steroids inhibits angiogenesis in the presence of heparin or a heparin fragment. Science ; 230:-.
Szabo S, Brown A, Pihan G, Dali H, Neumeyer JL. Duodenal ulcer induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine). Proc. Soc. Exp. Biol. Med. ; 180:567-571.
Szabo S, Horner HC, Maull H, Schnoor J, Chieuh CC, Palkovits M. Biochemical changes in tissue catecholamines and serotonin in duodenal ulceration caused by cysteamine or propionitrile in the rat. J. Pharmacol. Exp. Ther. ; 240:871-878.
Silver EH, Szabo S, Cahill M, Jaeger RJ. Time-course studies of the distribution of [1-14C] acrylonitrile in rats after intravenous administration. J. Appl. Toxicol. ; 7:303-306.
Szabo S, Rogers C. Diet, ulcer disease, and fish oil. Lancet ; 1:119.
Folkman J, Szabo S, Stovroff M. McNeil P, Li W, Shing Y. Duodenal ulcer: discovery of a new mechanism and development of angiogenic therapy that accelerates healing. Ann. Surg. ; 214:414-426.
Hauser J, Szabo S. Extremely long protection by pyrazole derivatives against chemically induced gastric mucosal injury. J. Pharmacol. Exp. Ther., ; 256:592-598.
Giampaolo C, Gray AT, Olshen RA, Szabo S. Predicting chemically induced duodenal ulcer and adrenal necrosis with classification trees. Proc. Natl. Acad. Sci. USA, ; 88:-.
Szabo S, Folkman J, Vattay P, Morales RE, Pinkus GS, Kato K. Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats. Gastroenterology ; 106:-.
Nagy L, Kusstatscher S, Hauschka PV, Szabo S. Role of cysteine proteases and protease inhibitors in gastric mucosal damage induced by ethanol or ammonia in the rat. J. Clin. Invest. ; 98:-.
Szabo S, Vincze A, Sandor Z, Jadus M, Gombo Z, Pedram A, Levin E, Hagar J, Iaquinto G. Vascular approach to gastroduodenal ulceration: new studies with endothelins and VEGF. Dig. Dis. Sci. ;4 3:40S-45S.
Khomenko T, Deng XM, Jadus MR, Szabo S. Effect of cysteamine on redox-sensitive thiol-containing proteins in the duodenal mucosa. Biochem. Biophys. Res. Comm. ;309:910-916.
Khomenko T, Deng XM, Sandor Zs, Tarnawski AS and S Szabo. Cysteamine alters redox state, HIF-1 transcriptional interactions and reduces duodenal mucosal oxygenation: novel insight into the mechanisms of duodenal ulceration Biochem. Biophys. Res. Commun. ; 317(1):121-127.
Deng XD, Szabo S, Jadus MR, Khomenko T, Yoshida M, Herlyn M, Nesbit M, Matsumoto H, Florsheim WH. Gene therapy with naked DNA or adenoviral vector of VEGF or PDGF increases endogenous VEGF, PDGF and bFGF expression and accelerates chronic duodenal ulcer healing in rats. J. Pharmacol. Exp. Ther. ; 311:982-988.
Khomenko T, Szabo S, Deng XM, Jadus M, Ishikawa H, Osapay K, Sandor Zs, Chen L. Suppression of early growth response factor– 1 with antisense oligodeoxynucleotide aggravates experimental duodenal ulcers. Am. J. Physiol., Gastrointest. Liver Physiol., ; 290:-.
Sandor Zs, Deng XM, Khomenko T, Tarnawski AS, Szabo S. Altered angiogenic balance in ulcerative colitis: A key to impaired healing? Biochem. Biophys. Res. Commun., ; 350:147-150.
Ozdemir V, Jamal MM, Osapay K, Jadus MR, Sandor Z, Hashemzadeh M, Szabo S. Cosegregation of gastrointestinal ulcers and schizophrenia in a large national inpatient discharge database: revisiting the “brain-gut axis” hypothesis in ulcer pathogenesis. J. Investig. Med. ; 55(6):315-20.
Deng X, Szabo S, Khomenko T, Jadus MR, Yoshida M, Chen L. Detection of duodenal ulcer-associated genes in rats. Dig. Dis. Sci. ; 53(2): 375-84.
Tolstanova G, Khomenko T, Deng XM, Chen L, Tarnawski A, Ahluwalia A, Szabo S, Sandor Z. Neutralizing anti-VEGF antibody reduces severity of experimental ulcerative colitis in rats. Direct evidence for the pathogenic role of VEGF. J. Pharmacol. Exp. Ther. ; 328:749-757.
Khomenko T, Szabo S, Deng XM, Ishikawa H, Anderson G J, McLaren GD. Role of iron in the pathogenesis of cysteamine-induced duodenal ulceration in rats. Am. J. Physiol. Gastrointest. Liver Physiol. ; 296: G-.
Deng XM, Tolstanova G, Khomenko T, Chen LC, Tanarwski AS, Szabo S, Sandor Zs. Mesalamine restores angiogenic balance in experimental ulcerative colitis by reducing expression of endostatin and angiostatin: Novel molecular mechanism for mesalamine’s therapeutic action. J. Pharmacol. Exp. Ther. ; 331:-.
Tolstanova G, Deng XM, Khomenko T, Garg P, Paunovic B, Chen LC, Sitaraman SV, Shiloach J, Szabo S, Sandor Zs. Role of anti-angiogenic factor endostatin in the pathogenesis of experimental ulcerative colitis. Life Sci. ; 88: 74-81.
Florkiewicz RZ, Ahluwalia A, Sandor Z, Szabo S, Tarnawski AS. Gastric mucosal injury activates bFGF gene expression and triggers preferential translation of high molecular weight bFGF isoforms through CUG-initiated, non-canonical codons. Biochem. Biophys. Res. Commun. ; 409:494-499.
Deng XM, Szabo S, Khomenko T, Xiong XM, Sandor Zs, Osapay K, Jadus MR, Tolstanova G, Shiloach J, Chen L. Inappropriate angiogenic response as a novel mechanism of duodenal ulceration and impaired healing. Dig. Dis. Sci. ; 56:-801.
Tolstanova G, Deng XM, French S, Lungo W, Paunovic B, Khomenko T, Ahluwalia A, Kaplan T, Dacosta-Iyer M, Tarnawski A, Szabo S, Sandor Zs. Early endothelial damage and increased colonic vascular permeability in the development of experimental ulcerative colitis in rats and mice. Lab. Invest. ; 92:9-21.
Paunovic B, Deng XM, Khomenko T, Ahluwalia A, Tolstanova G, Tarnawski A, Szabo S, Sandor Z. Molecular mechanisms of bFGF effect on healing of ulcerative colitis in rats. J. Pharmacol. Exp. Ther. ; 339:430-437.
Khomenko T, Kolodney J, Pinto JT, McLaren GD, Deng X, Chen L, Tolstanova G, Paunovic B, Krasnikov BF, Hoa N, Cooper AJ, Szabo S. New mechanistic explanation for the localization of ulcers in the rat duodenum: role of iron and selective uptake of cysteamine. Arch. Biochem. Biophys. ; 525:60-70.
Ahluwalia A, Jones MK, Deng XM, Sandor Zs, Szabo S, Andrzej S Tarnawski AS. An imbalance between VEGF and endostatin underlies impaired angiogenesis in gastric mucosa of aging rats. Am. J. Physiol. Gastrointest. Liver Physiol. ; 305: G325-332.
Khomenko T, Deng X, Ahluwalia A, Tarnawski T, Khushin P, Sandor Zs, Szabo S. STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration in rats and egr-1 knockout mice. Dig. Dis. Sci. ; 59:297-306.
Tolstanova G, Deng X, Ahluwalia A, Paunovic B, Prysiazhniuk A, Ostapchenko L, Tarnawski A, Sandor Z, Szabo S. Role of dopamine and D2 dopamine receptor in the pathogenesis of inflammatory bowel disease. Dig. Dis. Sci. ; 60:-.
Satoh H, Szabo S. A mutein of human basic fibroblast growth factor TGP-580 accelerates colonic ulcer healing by stimulating angiogenesis in the ulcer bed in rats. J. Physiol. Pharmacol. ; 66:719-729.
Szabo S, Yoshida M, Filakovszky J, Juhasz Gy. “Stress” is 80 years old: From Hans Selye original paper in to recent advances in GI ulceration. Curr. Pharm. Des. ; 23:-.
Szabo S. New developments in cell & tissue injury: Focus on PD-1, C1orf106 gene, cell junctions & IBD. Dig. Dis. Sci. (in press)
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